Two proteins with seven transmembrane‐spanning domains typical of guanosine‐nucleotide‐binding‐protein‐coupled
receptors have been identified as cannabinoid receptors; the …

Based on both binding and functional data, this study introduces SR 144528 as the first, highly
potent, selective and orally active antagonist for the CB2 receptor. This compound which …

In the present study, we showed that Chinese hamster ovary (CHO) cells transfected with
human central cannabinoid receptor (CB1) exhibit high constitutive activity at both levels of …

Marijuana and many of its constituent cannabinoids influence the central nervous system (CNS),
probably through the cannabinoid receptor, which has recently been cloned in rat and …

Cannabinoids, known for their psychoactive effects, also possess immunomodulatory
properties. The recent isolation and cloning of the G‐protein‐coupled peripheral cannabinoid …

We investigated the effects of anandamide on peroxisome proliferator-activated receptor γ (PPARγ)
activity. In two different transactivation systems using either full-length or only the …

In the present study, we observed evidence of cross-talk between the cannabinoid receptor
CB1 and the orexin 1 receptor (OX1R) using a heterologous system. When the two receptors …

Two subtypes of G-protein–coupled cannabinoid receptors have been identified to date: the
CB1 central receptor subtype, which is mainly expressed in the brain, and the CB2 …

The recent isolation and cloning of the G protein-coupled central cannabinoid receptor (CB1)
from brain tissue has provided a molecular basis to elucidate how cannabinoid …

We have investigated the pharmacology of two central human cannabinoid receptor
isoforms, designated CB1 and CB1A, stably expressed in Chinese hamster ovary cell lines, …