[HTML][HTML] Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants
…, EM Adkins, ML Parnas, RA Vaughan, MF Zou… - Journal of Biological …, 2006 - ASBMB
In previous studies examining the structural determinants of antidepressant and substrate
recognition by serotonin transporters (SERTs), we identified Tyr-95 in transmembrane …
recognition by serotonin transporters (SERTs), we identified Tyr-95 in transmembrane …
[HTML][HTML] Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists
…, D Economidou, DE Theobald, MF Zou… - …, 2012 - Springer
Rationale Impulsivity is associated with a number of psychiatric disorders, most notably
attention deficit/hyperactivity disorder (ADHD). Drugs that augment catecholamine function (eg …
attention deficit/hyperactivity disorder (ADHD). Drugs that augment catecholamine function (eg …
Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs
…, CB Vaegter, JH Cha, MF Zou… - Journal of …, 2009 - Soc Neuroscience
The dopamine transporter (DAT) mediates reuptake of dopamine from the synaptic cleft and
is a target for widely abused psychostimulants such as cocaine and amphetamine. …
is a target for widely abused psychostimulants such as cocaine and amphetamine. …
Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors
CJ Loland, RI Desai, MF Zou, J Cao, P Grundt… - Molecular …, 2008 - ASPET
Cocaine exerts its stimulatory effect by inhibiting the dopamine transporter (DAT). However,
novel benztropine- and rimcazole-based inhibitors show reduced stimulant effects compared …
novel benztropine- and rimcazole-based inhibitors show reduced stimulant effects compared …
[HTML][HTML] Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane
…, E Cabrera, B Felts, LK Henry, J Swant, MF Zou… - Nature …, 2016 - nature.com
The dopaminergic system is essential for cognitive processes, including reward, attention
and motor control. In addition to DA release and availability of synaptic DA receptors, timing …
and motor control. In addition to DA release and availability of synaptic DA receptors, timing …
[HTML][HTML] Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells
…, HJ Gruber, M Holy, AH Newman, MF Zou… - Journal of Biological …, 2012 - ASBMB
The serotonin transporter (SERT) terminates neurotransmission by removing serotonin from
the synaptic cleft. In addition, it is the site of action of antidepressants (which block the …
the synaptic cleft. In addition, it is the site of action of antidepressants (which block the …
Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism
The development of bivalent ligands has attracted interest as a way to potentially improve
the selectivity and/or affinity for a specific receptor subtype. The ability to bind two distinct …
the selectivity and/or affinity for a specific receptor subtype. The ability to bind two distinct …
Rhodamine-labeled 2β-carbomethoxy-3β-(3, 4-dichlorophenyl) tropane analogues as high-affinity fluorescent probes for the dopamine transporter
JH Cha, MF Zou, EM Adkins… - Journal of medicinal …, 2005 - ACS Publications
Novel fluorescent ligands were synthesized to identify a high-affinity probe that would
enable visualization of the dopamine transporter (DAT) in living cells. Fluorescent tags were …
enable visualization of the dopamine transporter (DAT) in living cells. Fluorescent tags were …
A novel mGluR5 antagonist, MFZ 10‐7, inhibits cocaine‐taking and cocaine‐seeking behavior in rats
TM Keck, MF Zou, GH Bi, HY Zhang, XF Wang… - Addiction …, 2014 - Wiley Online Library
Pre‐clinical studies suggest that negative allosteric modulators ( NAMs ) of the metabotropic
glutamate receptor subtype 5 ( mGluR5 ), including 2‐methyl‐6‐(phenylethynyl)pyridine ( …
glutamate receptor subtype 5 ( mGluR5 ), including 2‐methyl‐6‐(phenylethynyl)pyridine ( …
Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist …
Novel 1-, 5-, and 8-substituted analogues of sumanirole (1), a dopamine D 2 /D 3 receptor (D
2 R/D 3 R) agonist, were synthesized. Binding affinities at both D 2 R and D 3 R were …
2 R/D 3 R) agonist, were synthesized. Binding affinities at both D 2 R and D 3 R were …