Stimulation of immune cells causes depletion of Ca 2+ from endoplasmic reticulum (ER)
stores, thereby triggering sustained Ca 2+ entry through store-operated Ca 2+ release-activated …

Antigen stimulation of immune cells triggers Ca 2+ entry through Ca 2+ release-activated
Ca 2+ (CRAC) channels, promoting the immune response to pathogens by activating the …

Ca 2+ entry through store‐operated Ca 2+ release‐activated Ca 2+ (CRAC) channels
initiates key functions such as gene expression and exocytosis of inflammatory mediators. …

CRAC (calcium release-activated Ca 2+ ) channels attain an extremely high selectivity for
Ca 2+ from the blockade of monovalent cation permeation by Ca 2+ within the pore. In this …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in virtually
all metozoan cells and serve a wide variety of functions ranging from gene expression, …

It is widely appreciated that T cells increase glycolytic flux during activation, but the role of
mitochondrial flux is unclear. Here, we have shown that mitochondrial metabolism in the …

Store-operated Ca 2+ entry through calcium release–activated calcium channels is the chief
mechanism for increasing intracellular Ca 2+ in immune cells. Here we show that mouse T …

Ca 2+ -release-activated Ca 2+ (CRAC) channels generate sustained Ca 2+ signals that are
essential for a range of cell functions, including antigen-stimulated T lymphocyte activation …

… Murali Prakriya and Richard S Lewis … These results have been reported previously in
abstract form (Prakriya & Lewis, 2001b). … Prakriya M, Lewis RS. Store-operated calcium …

Lymphocyte function is regulated by a network of ion channels and transporters in the plasma
membrane of B and T cells. These proteins modulate the cytoplasmic concentrations of …