Liver X receptors (LXRs) are nuclear hormone receptors that regulate cholesterol and fatty
acid metabolism in liver tissue and in macrophages. Although LXR activation enhances …

Metabolic disorders, including type 2 diabetes and obesity, represent major health risks in
industrialized countries. AMP-activated protein kinase (AMPK) has become the focus of a …

In this study, we demonstrate that activation of AMP-activated protein kinase (AMPK) with
glabridin alleviates adiposity and hyperlipidemia in obesity. In several obese rodent models, …

Fas/APO-1/CD95, a member of the tumor necrosis factor (TNF) receptor superfamily, is a
potential anti-cancer factor as it can induce apoptosis in tumor cells. However, despite the fact …

Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are important
pathogenic mechanisms in atherosclerosis and restenosis after vascular injury. In this study…

The presence of excess glucose promotes hemoglobin glycation via the biochemical
modification of hemoglobin by dicarbonyl products. However, the precise effects of Hb-AGEs in …

Introduction Parkinson’s disease (PD) is a representative neurodegenerative disease, and
its diagnosis relies on the evaluation of clinical manifestations or brain neuroimaging in the …

Long-term administration of levodopa (L-DOPA) to patients with Parkinson’s disease (PD)
commonly results in involuntary dyskinetic movements, as is known for L-DOPA-induced …

Background and Aims: Excessive intake of advanced glycation end products (AGEs), which
are formed in foods cooked at high temperatures for long periods of time, has negative …

Accumulation of glucose/sugar results in the formation of reactive di-carbonyl compounds
such as MGO and GO that interact with several amino acids and proteins to form toxic …