Phosphorylation of AMPA receptors: mechanisms and synaptic plasticity

JQ Wang, A Arora, L Yang, NK Parelkar, G Zhang… - Molecular …, 2005 - Springer
The ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor is
densely distributed in the mammalian brain and is primarily involved in mediating fast …

Glutamate signaling to Ras-MAPK in striatal neurons: mechanisms for inducible gene expression and plasticity

JQ Wang, Q Tang, NK Parelkar, Z Liu, S Samdani… - Molecular …, 2004 - Springer
Extracellular signals can regulate mitogen-activated protein kinase (MAPK) cascades through
a receptor-mediated mechanism in postmitotic neurons of adult mammalian brain. Both …

[PDF][PDF] Modulation of D2R-NR2B interactions in response to cocaine

…, M Wang, HX Lan, MH Li, GC Zhang, NK Parelkar… - Neuron, 2006 - cell.com
Dopamine-glutamate interactions in the neostriatum determine psychostimulant action, but
the underlying molecular mechanisms remain elusive. Here we found that dopamine …

Phosphorylation of glutamate receptors: a potential mechanism for the regulation of receptor function and psychostimulant action

JQ Wang, X Liu, G Zhang, NK Parelkar… - Journal of …, 2006 - Wiley Online Library
Ionotropic glutamate receptors, N‐methyl‐d‐aspartate receptors (NMDARs) and α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic
acid receptors (AMPARs), are densely distributed …

In vivo regulation of Homer1a expression in the striatum by cocaine

GC Zhang, LM Mao, XY Liu, NK Parelkar, A Arora… - Molecular …, 2007 - ASPET
The glutamate receptor adaptor protein Homer is concentrated in the postsynaptic density of
excitatory synapses and is critical for normal operation of synaptic transmission. In this study…

The protein phosphatase 1/2A inhibitor okadaic acid increases CREB and Elk‐1 phosphorylation and c‐fos expression in the rat striatum in vivo

ES Choe, NK Parelkar, JY Kim, HW Cho… - Journal of …, 2004 - Wiley Online Library
Activation of group I metabotropic glutamate receptors (mGluRs) up‐regulates transcription
factor cyclic AMP response element‐binding protein (CREB) and Elk‐1 phosphorylation via …

Protein Kinase A–Phosphorylated KV1 Channels in PSD95 Signaling Complex Contribute to the Resting Membrane Potential and Diameter of Cerebral Arteries

CL Moore, PL Nelson, NK Parelkar, NJ Rusch… - Circulation …, 2014 - Am Heart Assoc
Rationale: Postsynaptic density-95 (PSD95) is a scaffolding protein that associates with
voltage-gated, Shaker-type K + (K V 1) channels and promotes the expression of K V 1 channels …

A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct

AL Wolfe, KK Duncan, NK Parelkar… - Journal of Medicinal …, 2012 - ACS Publications
A unique heterocyclic carbamate prodrug of seco-CBI-indole 2 that releases no residual
byproduct is reported as a new member of a class of hydrolyzable prodrugs of the duocarmycin …

Hyperbaric oxygen improves engraftment of ex-vivo expanded and gene transduced human CD34+ cells in a murine model of umbilical cord blood transplantation

OS Aljitawi, Y Xiao, JD Eskew, NK Parelkar… - Blood Cells, Molecules …, 2014 - Elsevier
Delayed engraftment and graft failure represent major obstacles to successful umbilical
cord blood (UCB) transplantation. Herein, we evaluated the use of hyperbaric oxygen (HBO) …

[HTML][HTML] Phosphatidylinositol 3, 5-bisphosphate (PI (3, 5) P2) potentiates cardiac contractility via activation of the ryanodine receptor

…, IK Bales, JK Stone, TJ Rohrberg, NK Parelkar… - Journal of biological …, 2010 - ASBMB
Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is the most recently identified phosphoinositide,
and its functions have yet to be fully elucidated. Recently, members of our muscle …