[HTML][HTML] Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia [S]

…, VH Mendoza, K Gagen, NS Geoghagen… - Journal of lipid …, 2012 - ASBMB
In an attempt to understand the applicability of various animal models to dyslipidemia in
humans and to identify improved preclinical models for target discovery and validation for …

Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications

TG Holt, BK Choi, NS Geoghagen… - ASSAY and Drug …, 2009 - liebertpub.com
Label-free mass spectrometric (MS) technologies are particularly useful for enzyme assay
design for drug discovery screens. MS permits the selective detection of enzyme substrates or …

Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters

…, R Rosa, V Shah, T He, SJ Stout, NS Geoghagen… - Metabolism, 2012 - Elsevier
The objective was to assess whether pharmacological activation of lecithin cholesterol
acyltransferase (LCAT) could exert beneficial effects on lipoprotein metabolism. A putative small …

Alanine scanning mutagenesis of conserved arginine/lysine-arginine/lysine-XX-arginine/lysine G protein-activating motifs on m1 muscarinic acetylcholine receptors.

NH Lee, NS Geoghagen, E Cheng, RT Cline… - Molecular …, 1996 - ASPET
Alanine scanning mutagenesis of BBXXB motifis (where B is a basic residue and X is any
nonbasic residue) in m1 muscarinic acetylcholine receptors was performed to determine the …

Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice

KK Jensen, NS Geoghagen, L Jin, TG Holt… - European journal of …, 2011 - Elsevier
Hydrogen sulfide (H 2 S) is a recently discovered gasotransmitter found in mammalian
tissues and blood. Treatment with H 2 S donor molecules has shown promising results in …

Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd

…, JL Fritchman, JL Fuhrmann, NSM Geoghagen… - science, 1995 - science.org
An approach for genome analysis based on sequencing and assembly of unselected pieces
of DNA from the whole chromosome has been applied to obtain the complete nucleotide …

Expanding the Scope of HTMS Methods

…, X Chen, BK Choi, NS Geoghagen… - … for Drug Discovery, 2011 - Wiley Online Library
A label-free enzyme assay based on mass spectrometric quantification of the product of an
enzymatic reaction has been developed. The product, cystathionine, a polar dipeptide, was …

Treatment with controlled-release lovastatin decreases serum concentrations of human β-amyloid (Aβ) peptide

LT Friedhoff, EI Cullen, NSM Geoghagen… - International Journal …, 2001 - academic.oup.com
The deposition of β-amyloid (Aβ) in neuronal plaques is believed to be crucial for the initiation
and progression of Alzheimer's disease (AD). Studies in vitro have shown that inhibiting …

A general use of the Poisson approximation for binomial events, with application to bacterial endocarditis data

HB Eisenberg, RRM Geoghagen, JE Walsh - Biometrics, 1966 - JSTOR
The use of past data to predict future results is the goal of much medical research.
Unfortunately, even partial attainment of this goal is ordinarily difficult. For two special types of …

[CITATION][C] M., Weidman, JF, Fuhrmann, JL, Nguyen, D., Utterback

…, JM Merrick, A Glodek, JL Scott, NS Geoghagen - 1996 - TR, Kelley, JM, Peterson, JD, Sadow …