Fosfomycin is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative
activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by …

Colistin (polymyxin E) is a positively charged deca-peptide antibiotic that disrupts the integrity
of the outer membrane of the cell wall of gram-negative bacteria by binding to the lipid A …

CC Chemokine Receptor 2 (CCR2) and its endogenous ligand CCL2 are involved in a number
of diseases, including atherosclerosis. Several CCR2 antagonists have been developed …

… Ortiz Zacarías … Ortiz Zacarías … Ortiz Zacarías - Division of Drug Discovery and Safety, Leiden
Academic Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA Leiden, The …

… Ortiz Zacarías … Ortiz Zacarías … Ortiz Zacarías - Division of Drug Discovery and Safety,
Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands; …

CC chemokine receptors 2 (CCR2) and 5 (CCR5) are involved in many inflammatory
diseases; however, most CCR2 and CCR5 clinical candidates have been unsuccessful. (Pre)…

Fosfomycin as a potential therapy for the treatment of systemic infections: a population
pharmacokinetic model to simulate multiple dosing regimens - Ortiz Zacarías - 2018 - …

Herein we report the design and synthesis of a series of highly selective CCR2 antagonists
as 18 F‐labeled PET tracers. The derivatives were evaluated extensively for their off‐target …

Part I, Chapter 3 of the Handbook was dedicated to the complementary function of
mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling pathways that need to …

The chemokine signaling axes CCR2-CCL2 and CXCR3-CXCL11 participate in the
inflammatory response by recruiting leukocytes to damaged tissue or sites of infection and are, …