[HTML][HTML] Fosfomycin: pharmacological, clinical and future perspectives
AC Dijkmans, NV Ortiz Zacarías, J Burggraaf… - Antibiotics, 2017 - mdpi.com
Fosfomycin is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative
activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by …
activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by …
Colistin: revival of an old polymyxin antibiotic
…, W Birkhoff, NV Ortiz-Zacarías… - Therapeutic drug …, 2015 - journals.lww.com
Colistin (polymyxin E) is a positively charged deca-peptide antibiotic that disrupts the integrity
of the outer membrane of the cell wall of gram-negative bacteria by binding to the lipid A …
of the outer membrane of the cell wall of gram-negative bacteria by binding to the lipid A …
[HTML][HTML] A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy
I Bot, NV Ortiz Zacarías, WEA de Witte, H de Vries… - Scientific reports, 2017 - nature.com
CC Chemokine Receptor 2 (CCR2) and its endogenous ligand CCL2 are involved in a number
of diseases, including atherosclerosis. Several CCR2 antagonists have been developed …
of diseases, including atherosclerosis. Several CCR2 antagonists have been developed …
Pyrrolone derivatives as intracellular allosteric modulators for chemokine receptors: selective and dual-targeting inhibitors of CC chemokine receptors 1 and 2
NV Ortiz Zacarías, JPD van Veldhoven… - Journal of Medicinal …, 2018 - ACS Publications
… Ortiz Zacarías … Ortiz Zacarías … Ortiz Zacarías - Division of Drug Discovery and Safety, Leiden
Academic Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA Leiden, The …
Academic Centre for Drug Research, Leiden University, PO Box 9502, 2300 RA Leiden, The …
Design and characterization of an intracellular covalent ligand for CC chemokine receptor 2
NV Ortiz Zacarías, KK Chahal… - Journal of Medicinal …, 2021 - ACS Publications
… Ortiz Zacarías … Ortiz Zacarías … Ortiz Zacarías - Division of Drug Discovery and Safety,
Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands; …
Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands; …
Synthesis and pharmacological evaluation of triazolopyrimidinone derivatives as noncompetitive, intracellular antagonists for CC chemokine receptors 2 and 5
NV Ortiz Zacarías, JPD van Veldhoven… - Journal of Medicinal …, 2019 - ACS Publications
CC chemokine receptors 2 (CCR2) and 5 (CCR5) are involved in many inflammatory
diseases; however, most CCR2 and CCR5 clinical candidates have been unsuccessful. (Pre)…
diseases; however, most CCR2 and CCR5 clinical candidates have been unsuccessful. (Pre)…
Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens
NV Ortiz Zacarías, AC Dijkmans… - Pharmacology …, 2018 - Wiley Online Library
Fosfomycin as a potential therapy for the treatment of systemic infections: a population
pharmacokinetic model to simulate multiple dosing regimens - Ortiz Zacarías - 2018 - …
pharmacokinetic model to simulate multiple dosing regimens - Ortiz Zacarías - 2018 - …
Development of the first potential nonpeptidic positron emission tomography tracer for the imaging of CCR2 receptors
…, F de Moura Gatti, DG Silva, NV Ortiz Zacarias… - …, 2021 - Wiley Online Library
Herein we report the design and synthesis of a series of highly selective CCR2 antagonists
as 18 F‐labeled PET tracers. The derivatives were evaluated extensively for their off‐target …
as 18 F‐labeled PET tracers. The derivatives were evaluated extensively for their off‐target …
Manipulating the brain corticosteroid receptor balance: focus on ligands and modulators
E De Kloet, NV Ortiz Zacarias… - … handbook of stress, 2017 - books.google.com
Part I, Chapter 3 of the Handbook was dedicated to the complementary function of
mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling pathways that need to …
mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling pathways that need to …
[BOOK][B] Mei er
F Sommer, NV Ortiz Zacarıas, LH Heitman - 2021 - scholarlypublications …
The chemokine signaling axes CCR2-CCL2 and CXCR3-CXCL11 participate in the
inflammatory response by recruiting leukocytes to damaged tissue or sites of infection and are, …
inflammatory response by recruiting leukocytes to damaged tissue or sites of infection and are, …