We sought to determine whether nucleolin, a bcl-2 mRNA-binding protein, has a role in the
regulation of bcl-2 mRNA stability in MCF-7 and MDA-MB-231 breast cancer cells. …

We report the results of a multicenter phase 1 dose-escalation study of the selective Bruton
tyrosine kinase (BTK) inhibitor ONO/GS-4059 in 90 patients with relapsed/refractory B-cell …

AS1411 is a DNA aptamer that is in phase II clinical trials for relapsed or refractory acute
myeloid leukemia and for renal cell carcinoma. AS1411 binds to nucleolin, a protein that is …

Human anti-mouse immunoglobulin immune responses were studied in ten patients, eight
with ovarian cancer and two with grade IV gliomas, diagnosed and treated with radiolabeled ( …

Integrins are cell-surface glycoproteins found in different forms on all cells except erythrocytes.
Integrins bind to cell adhesion molecules and to proteins found in the extracellular matrix. …

Twenty-seven patients with brain glioma were scanned using 1@ l-labeledmonoclonal
antibodies against epidermal growth factor receptor (EGFR1) or placental alkaline phosphatase (…

The development of stable immunoconjugates by the advent of macrocyclic metal chelating
agents (DOTA) has enabled us to study the ability of 111 In-DOTA-labeled monoclonal …

IL-12 is a cytokine which showed anti-tumor effects in clinical trials, but also produced
serious toxicity. We describe a fusion protein, huBC1-IL12, designed to achieve an improved …

Addition of cholera toxin (100 ng/ml) to quiescent cultures of Swiss 3T3 cells acts synergistically
with serum (2-4%), insulin, phorbol esters, epidermal growth factor, and fibroblast-…

ED-B fibronectin (FN) is a FN isoform derived from alternative splicing of the primary transcript
of a single gene. Its expression on tumor stroma and neoformed tumor vasculature and its …