The binding characteristics of 33 P-2MeS-ADP, a stable analogue of ADP, were determined
on CHO cells transfected with the human P2Y 12 receptor, a novel purinergic receptor. …

The effects of somatostatin analogues RC-160 and SMS-201-995 on tyrosine phosphatase
and cell proliferation were investigated in COS-7 and NIH 3T3 cells expressing human …

… After an overnight attachment phase (time 0), cells were cultured for 24 h in serum-free
αMEM or in αMEM containing 10% FCS with or without 1 nm SMS. Cell growth was measured at …

We investigated cell proliferation modulated by cholecystokinin (CCK) and somatostatin
analogue RC-160 in CHO cells bearing endogenous CCK A receptors and stably transfected by …

We have previously reported in Chinese hamster ovary (CHO) cells expressing sst2 that
activation of the sst2 somatostatin receptor inhibits insulin-induced cell proliferation by a …

Human pancreatic adenocarcinomas lose the ability to express sst2, the somatostatin receptor,
which mediates the antiproliferative effect of somatostatin. Reintroducing sst2 into human …

A protein of 66 kd immunoreactive to anti-tyrosine phosphatase (PTP1C) antibodies coeluted
with, and so may be associated with, somatostatin receptors (ssts) from rat pancreatic …

… ; n = 610, MANTA; n = 321) individually showed no statistically significant differences in
systemic SAEs between ranibizumab and bevacizumab [16, 17], a recent meta-analysis (n = …

In the search of a potential backup for clopidogrel, we have initiated a HTS campaign designed
to identify novel reversible P2Y12 antagonists. Starting from a hit with low micromolar …

P2Y12, a G protein-coupled receptor that plays a central role in platelet activation has been
recently identified as the receptor targeted by the antithrombotic drug, clopidogrel. In this …