A simple and sensitive automated method, consisting of in-tube solid-phase microextraction
(SPME) coupled with high-performance liquid chromatography-fluorescence detection (…

A simple and sensitive automated method for determination of aflatoxins (B1, B2, G1, and
G2) in nuts, cereals, dried fruits, and spices was developed consisting of in-tube solid-phase …

1. The human liver UDP-glucuronosyltransferase (UGT) isoforms involved in the glucuronidation
of 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan (CPT-11)…

Bisphenol A (BPA) is one of a number of potential endocrine disruptors which may affect
normal hormonal function. In this study, human UDP-glucuronosyltransferase (UGT) isoforms …

The debrisoquine polymorphism is a common genetic defect that results in deficient oxidation
of debrisoquine and numerous other drugs. These compounds are metabolized by a form …

Cytochrome P450 (P450) 2B6 is a hepatic enzyme of potential importance for the metabolism
of clinically used drugs and environmental or abused toxicants. Genetic polymorphisms …

We examined the effect of bisphenol A (BPA) on microsomal cytochrome P450 (P450) enzymes
in rats. Rats were treated intraperitoneally with BPA daily for 4 days, at doses of 10, 20, …

Species difference in glucuronidation of morphine was studied using mice, rats, guinea pigs
and rabbits in vivo and in vitro. Morphine-3-glucuronide (M-3-G) and morphine-6—…

… The pEXP1-DEST vector is designed to introduce a 6× His-tag at the N-terminus of the …
GSTO1-1 comprises two domains, an N-terminal thioredoxin-like domain and a C-terminal …

… in COS-1 cells, and their kinetic parameters for SN-38 glucuronidation were determined by
the high-performance liquid chromatography method with fluorescence detection (Hanioka et …