Activity‐dependent, bidirectional control of synaptic efficacy is thought to contribute to many
forms of experience‐dependent plasticity, including learning and memory. Although most …

The CA3 region of the hippocampus is important for rapid encoding of memory. Computational
theories have proposed specific roles in hippocampal function and memory for the sparse …

Single-wavelength fluorescent reporters allow visualization of specific neurotransmitters
with high spatial and temporal resolution. We report variants of intensity-based glutamate-…

The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the
present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) …

The physiological conditions under which adenosine A 2A receptors modulate synaptic
transmission are presently unclear. We show that A 2A receptors are localized postsynaptically …

Adenosine A 2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A 2A receptors are considerably …

… biochemical changes (p38 and c-jun N-terminal kinase phosphorylation and caspase 3
activation… The LPS-induced increases in phosphorylation of c-jun N-terminal kinase and p38 and …

… Pellets were resuspended and incubated with 3 nm 3 H-ZM241385 (specific activity of 77
Ci/mmol; GE Healthcare, Piscataway, NJ) for 1 h at 37C. Specific binding was determined by …

… facilitation of glutamate release by 10 nm CGS21680 was prevented by 10 μm MPEP,
whereas facilitation by 300 μm CHPG was prevented by 10 nm SCH58261. These results provide …

Adenosine is a neuromodulator that controls neurotransmitter release through inhibitory A 1
and facilitatory A 2A receptors. Although both adenosine receptor-mediated inhibition and …