Regioselective and stereospecific glucuronidation of trans-and cis-resveratrol in human

…, JM Mérillon, J Magdalou, N Sabolovic - Archives of biochemistry …, 2001 - Elsevier
… The reactions were terminated by the addition of 0.6 N HCl (final concentration) in ice. The
… The reaction was stopped by the addition of 0.6 N HCl. After precipitation of the proteins, the …

Resveratrol is efficiently glucuronidated by UDP‐glucuronosyltransferases in the human gastrointestinal tract and in Caco‐2 cells

N Sabolovic, AC Humbert… - … & drug disposition, 2006 - Wiley Online Library
Resveratrol (3, 5, 4′‐trihydroxy‐trans‐stilbene), a natural polyphenol present in grapes and
peanuts, has been reported to exert a variety of potentially therapeutic effects. The aim of …

Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors.

K Bohnet, T Pillot, S Visvikis, N Sabolovic… - Journal of lipid research, 1996 - Elsevier
The clinical relevance of apoE concentration in lipoprotein fractions should be evaluated. We
investigated the impact of the common apolipoprotein (apo) E polymorphism in conjunction …

Stable expression of two human UDP-glucuronosyltransferase cDNAs in V79 cell cultures.

S Fournel-Gigleux, L Sutherland, N Sabolovic… - Molecular …, 1991 - ASPET
Two human liver UDP-glucuronosyltransferase cDNA clones (HLUGP1 and HLUG25) were
individually inserted into the eukaryotic expression vector pKCRH2. Each recombinant …

Glucuronidation in the Caco-2 human intestinal cell line: induction of UDP-glucuronosyltransferase 1∗ 6

A Abid, I Bouchon, G Siest, N Sabolovic - Biochemical pharmacology, 1995 - Elsevier
The ability of the differentiated human intestinal cell line, Caco-2, to glucuronidate various
endobiotic and xenobiotic molecules was investigated. Glucuronidation of hydroxylated or …

Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7

N Sabolovic, J Magdalou, P Netter, A Abid - Life sciences, 2000 - Elsevier
… After incubation at 37 C for 30 (for naproxen and carprofen) or 40 min (for ketoprofen), the
reaction was stopped by addition of 10 l of 6 N HCl. The precipitated proteins were removed …

cis- and trans-Resveratrol Are Glucuronidated in Rat Brain, Olfactory Mucosa and Cultured Astrocytes

N Sabolovic, T Heurtaux, AC Humbert, S Krisa… - Pharmacology, 2007 - karger.com
… 33 383 68 39 60, Fax +33 383 68 39 59 E-Mail nicole.sabolovic@medecine.uhp-nancy.fr …
After incubation at 37C for 60 min, reactions were stopped by addition of 6 N HCl …

T-and B-cell surface markers on rabbit lymphocytes.

N Sabolović, D Sabolović, AM Guilmin - Immunology, 1977 - ncbi.nlm.nih.gov
Rabbit thymus, appendix, blood and lymph nodes were characterized using immunological
tests: rosette-forming ability with homologous or heterologous red blood cells, surface …

Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract

N Sabolovic, JM Heydel, X Li, JM Little… - … et Biophysica Acta (BBA …, 2004 - Elsevier
… The reactions were stopped with 50-μl 6 N HCl and samples were prepared for HPLC as
described above for the enzymatic activity assays. The biosynthesized glucuronides were …

Expression and regulation of drug metabolizing enzymes in an immortalized rat hepatocyte cell line

J Bayad, D Bagrel, N Sabolovic, J Magdalou… - Biochemical …, 1991 - Elsevier
A hepatic cell line has been immortalized after simian vacuolating virus 40 infection of adult
rat hepatocytes maintained in denned culture conditions. This cell line, designated SVHep …