Dietary Alkaloid Sequestration in a Poison Frog: An Experimental Test of Alkaloid Uptake in Melanophryniscus stelzneri (Bufonidae)

…, S Reinsch, D Mcginnity, M Loring, N Toyooka… - Journal of chemical …, 2013 - Springer
… of 1 N HCl were added to 1 ml of the original MeOH extract. The combined MeOH extract was
then concentrated with N 2 … with N 2 , and finally resuspended in 100 μl of 100 % methanol. …

Targeting Pancreatic Cancer with Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, In Vitro and In Vivo Evaluation

…, T Maruyama, T Okada, N Toyooka - Journal of Medicinal …, 2023 - ACS Publications
Pancreatic tumors grow in an “austerity” tumor microenvironment characterized by nutrient
deprivation and hypoxia. This leads to the activation of adaptive pathways in pancreatic …

Development of novel AKR1C3 inhibitors as new potential treatment for castration-resistant prostate cancer

…, N Fujimoto, T Nakayama, N Toyooka… - Journal of medicinal …, 2020 - ACS Publications
… In this study, we found a novel potent AKR1C3 inhibitor, N-(4-fluorophenyl)-8-hydroxy-2-imino-2H-chromene-3-carboxamide
(2d), and synthesized its derivatives with IC 50 values of 25…

[HTML][HTML] Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H2S/Cav3.2 Signaling in Mice

…, M Nishibori, HD Nguyen, T Okada, N Toyooka… - Cells, 2020 - mdpi.com
… that CPA causes ATP-dependent macrophage infiltration and ROS generation in the
bladder [13,14], we tested whether antagonists of purinergic P2X 7 and P2X 4 receptors and N-…

Alkaloids indolizidine 235B′, quinolizidine 1-epi-207I, and the tricyclic 205B are potent and selective noncompetitive inhibitors of nicotinic acetylcholine receptors

H Tsuneki, Y You, N Toyooka, S Kagawa… - Molecular …, 2004 - ASPET
… current response (in the absence of antagonist for inhibitory curves), An is the antagonist
concentration, IC 50 is the antagonist concentration eliciting half-maximal current, and n H is …

Critical role of Cav3. 2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice

…, S Yoshida, H Du Nguyen, T Okada, N Toyooka… - Toxicology, 2019 - Elsevier
Bortezomib, a first-line agent for treatment of multiple myeloma, exhibits anticancer activity
through proteasome inhibition. However, bortezomib-induced peripheral neuropathy (BIPN) is …

Highly Potent Antiausterity Agents from Callistemon citrinus and Their Mechanism of Action against the PANC-1 Human Pancreatic Cancer Cell Line

…, AM Omar, DF Dibwe, J Ueda, N Toyooka… - Journal of Natural …, 2020 - ACS Publications
… Workup of this extract resulted in the isolation of three new meroterpenoids, callistrilones
L–N (1–3), together with 14 known compounds (4–17). The structure elucidation of the new …

Design and Pharmacological Chaperone Effects of N-(4′-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase

…, H Ikeda, T Okada, N Toyooka - Journal of Medicinal …, 2023 - ACS Publications
… (15,36) This paper develops an original strategy for N-alkylated pyrrolidine iminosugars …
of the N-alkyl chain as a spacer moiety and the substituents in the terminal benzene ring of N-(4…

Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis

…, K Sundaram, O El-Kabbani, N Toyooka… - Journal of natural …, 2012 - ACS Publications
The human aldo-keto reductase (AKR) 1C3, also known as type-5 17β-hydroxysteroid
dehydrogenase and prostaglandin F synthase, has been suggested as a therapeutic target in the …

Marine alkaloids (−)-pictamine and (−)-lepadin B block neuronal nicotinic acetylcholine receptors

H Tsuneki, Y You, N Toyooka, T Sasaoka… - Biological and …, 2005 - jstage.jst.go.jp
MATERIALS AND METHODS Materials All alkaloids used in this study were synthesized
and are shown in Fig. 1. The synthesis of ()-pictamine and ()-lepadin B was performed as …