Anti‐proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down‐regulation and …
M Mimeault, N Pommery, N Wattez, C Bailly… - The …, 2003 - Wiley Online Library
… The apoptotic/necrotic responses induced by ANA on these prostatic cancer cells were also
potentiated by the acidic ceramidase inhibitor, N‐oleoylethanolamine and partially inhibited …
potentiated by the acidic ceramidase inhibitor, N‐oleoylethanolamine and partially inhibited …
Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis
…, A Lansiaux, A Wattelet, N Wattez… - European journal of …, 2000 - Elsevier
… For cryptolepine, the two nitrogen atoms of the indole ring and the N-methyl quinoline ring
are situated on the opposite side of the planar molecule. In 1996, a new alkaloid for which the …
are situated on the opposite side of the planar molecule. In 1996, a new alkaloid for which the …
Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins
…, MP Hildebrand, V Peyrot, N Wattez - Journal of medicinal …, 2003 - ACS Publications
A series of A-ring polymethoxylated neoflavonoids was prepared by ligand coupling reactions
involving either Suzuki or Stille reactions. Cytotoxicity studies indicated a potent activity …
involving either Suzuki or Stille reactions. Cytotoxicity studies indicated a potent activity …
Mechanisms underlying resistance to cetuximab in the HNSCC cell line: role of AKT inhibition in bypassing this resistance
…, P Peixoto, A Dewitte, N Wattez… - International …, 2011 - spandidos-publications.com
EGFR is frequently overexpressed in head and neck squamous cell cancer (HNSCC).
Cetuximab is a monoclonal antibody designed to interact with EGFR, block its activation, reduce …
Cetuximab is a monoclonal antibody designed to interact with EGFR, block its activation, reduce …
Effects of vitamin D3 derivatives on growth, differentiation and apoptosis in tumoral colonic HT 29 cells: possible implication of intracellular calcium
B Vandewalle, N Wattez, J Lefebvre - Cancer letters, 1995 - Elsevier
In addition to the effects on tumor cell differentiation and growth inhibition, vitamin D 3 derivatives
may exert other cellular actions such as the inhibition of angiogenesis or the induction …
may exert other cellular actions such as the inhibition of angiogenesis or the induction …
Inhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells
L Dassonneville, N Wattez, B Baldeyrou… - Biochemical …, 2000 - Elsevier
Ascididemin (ASC) is a pentacyclic DNA-intercalating agent isolated from the Mediterranean
ascidian Cystodytes dellechiajei. This marine alkaloid exhibits marked cytotoxic activities …
ascidian Cystodytes dellechiajei. This marine alkaloid exhibits marked cytotoxic activities …
Chromophore-modified bisnaphthalimides: DNA recognition, topoisomerase inhibition, and cytotoxic properties of two mono-and bisfuronaphthalimides
C Bailly, C Carrasco, A Joubert, C Bal, N Wattez… - Biochemistry, 2003 - ACS Publications
… The aminoalkyl linker chain found in elinafide [(CH 2 ) 2 -NH-(CH 2 ) 3 -NH-(CH 2 ) 2 ]
separates the two chromophores by ∼12.3 Ĺ [N−N distance for the fully extended form estimated …
separates the two chromophores by ∼12.3 Ĺ [N−N distance for the fully extended form estimated …
Apoptotic response of HL-60 human leukemia cells to the antitumor drug TAS-103
J Kluza, A Lansiaux, N Wattez, C Mahieu, N Osheroff… - Cancer research, 2000 - AACR
… Using a conventional tetrazolium-based MTS assay (11), we evaluated the IC 50 to 40 nm …
This double-stained cell fraction represents 21% of the cells on treatment with 50 nm TAS-…
This double-stained cell fraction represents 21% of the cells on treatment with 50 nm TAS-…
Relationship between cell cycle changes and variations of the mitochondrial membrane potential induced by etoposide
M Facompré, N Wattez, J Kluza, A Lansiaux… - Molecular Cell Biology …, 2000 - Elsevier
Etoposide, a clinically useful anticancer drug, is a potent inhibitor of topoisomerase II. The
DNA strand breaks caused by this epipodophyllotoxin lead to apoptotic death of tumor cells. …
DNA strand breaks caused by this epipodophyllotoxin lead to apoptotic death of tumor cells. …
Vitamin‐D3 derivatives and breast‐tumor cell growth: Effect on intracellular calcium and apoptosis
B Vandewalle, L Hornez, N Wattez… - … journal of cancer, 1995 - Wiley Online Library
… MCF-7-estrogen-receptor(ER)-positive and MDA-MB-231ER-negative breast-cancer
cells were routinely grown in MEM supplemented with 20 mM hydroxyethylpiperazine-N'-2…
cells were routinely grown in MEM supplemented with 20 mM hydroxyethylpiperazine-N'-2…