… Authorship note: Thomas Boettger and Nadine Beetz contributed equally to this work. …
Authorship note: Thomas Boettger and Nadine Beetz contributed equally to this work. …

Apelin constitutes a novel endogenous peptide system suggested to be involved in a broad
range of physiological functions, including cardiovascular function, heart development, …

We report that mice lacking the heterogeneous nuclear ribonucleoprotein U (hnRNP U) in
the heart develop lethal dilated cardiomyopathy and display numerous defects in cardiac pre-…

Nemaline myopathy (NM) is a congenital myopathy that can result in lethal muscle dysfunction
and is thought to be a disease of the sarcomere thin filament. Recently, several proteins …

α 2 -Adrenoceptors belong to the group of nine adrenoceptors which mediate the biological
actions of the endogenous catecholamines adrenaline and noradrenaline. Studies with gene…

α 2 -Adrenoceptors mediate diverse functions of the sympathetic system and are targets for
the treatment of cardiovascular disease, depression, pain, glaucoma, and sympathetic …

Rationale: In chronic heart failure, increased adrenergic activation contributes to structural
remodeling and altered gene expression. Although adrenergic signaling alters histone …

Background— Inhibition of cardiac sympathetic tone represents an important strategy for
treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and chronic …

Aims Biglycan, a small leucine-rich proteoglycan, has been shown to play an important role
in stabilizing fibrotic scars after experimental myocardial infarction. However, the role of …

Objectives Fixed-dose combination (FDC) therapy can improve outcomes in type 2 diabetes
(T2D). We evaluated the bioequivalence of 2 doses of an FDC of extended-release …