Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
H Watanabe, N Chopra, D Laver, HS Hwang… - Nature medicine, 2009 - nature.com
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal
inherited arrhythmia syndrome in which drug therapy is often ineffective. We discovered that …
inherited arrhythmia syndrome in which drug therapy is often ineffective. We discovered that …
[HTML][HTML] Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular …
BC Knollmann, N Chopra, T Hlaing… - The Journal of …, 2006 - Am Soc Clin Investig
Cardiac calsequestrin (Casq2) is thought to be the key sarcoplasmic reticulum (SR) Ca 2+
storage protein essential for SR Ca 2+ release in mammalian heart. Human CASQ2 mutations …
storage protein essential for SR Ca 2+ release in mammalian heart. Human CASQ2 mutations …
Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass
…, D Laver, Z Yang, SJ Le Marchand, N Chopra… - Journal of molecular and …, 2010 - Elsevier
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is linked to mutations in the
cardiac ryanodine receptor (RyR2) or calsequestrin. We recently found that the drug …
cardiac ryanodine receptor (RyR2) or calsequestrin. We recently found that the drug …
Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation–contraction coupling, and cardiac arrhythmias
Heart muscle excitation–contraction (EC) coupling is governed by Ca 2+ release units (CRUs)
whereby Ca 2+ influx via L-type Ca 2+ channels (Cav1.2) triggers Ca 2+ release from …
whereby Ca 2+ influx via L-type Ca 2+ channels (Cav1.2) triggers Ca 2+ release from …
Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro
…, B Leake, L Hall, S Kupershmidt, N Chopra… - Circulation, 2011 - Am Heart Assoc
Background— The D1275N SCN5A mutation has been associated with a range of unusual
phenotypes, including conduction disease and dilated cardiomyopathy, as well as atrial and …
phenotypes, including conduction disease and dilated cardiomyopathy, as well as atrial and …
Modest Reductions of Cardiac Calsequestrin Increase Sarcoplasmic Reticulum Ca2+ Leak Independent of Luminal Ca2+ and Trigger Ventricular Arrhythmias in …
N Chopra, PJ Kannankeril, T Yang, T Hlaing… - Circulation …, 2007 - Am Heart Assoc
Cardiac calsequestrin–null mice (Casq2 −/− ) display catecholaminergic ventricular
tachycardia akin to humans with CASQ2 mutations. However, the specific contribution of Casq2 …
tachycardia akin to humans with CASQ2 mutations. However, the specific contribution of Casq2 …
Azithromycin causes a novel proarrhythmic syndrome
…, RA Pickett, CM Shaffer, N Chopra… - Circulation …, 2017 - Am Heart Assoc
Background— The widely used macrolide antibiotic azithromycin increases risk of cardiovascular
and sudden cardiac death, although the underlying mechanisms are unclear. Case …
and sudden cardiac death, although the underlying mechanisms are unclear. Case …
A common β1-adrenergic receptor polymorphism predicts favorable response to rate-control therapy in atrial fibrillation
B Parvez, N Chopra, S Rowan, JC Vaglio… - Journal of the American …, 2012 - jacc.org
Objectives : In this study, we evaluated the impact of 2 common β1-adrenergic receptor (β1-AR)
polymorphisms (G389R and S49G) in response to ventricular rate control therapy in …
polymorphisms (G389R and S49G) in response to ventricular rate control therapy in …
Initial impedance decrease as an indicator of good catheter contact: insights from radiofrequency ablation with force sensing catheters
…, S Knecht, C Lane, M Kühne, E Nof, N Chopra… - Heart Rhythm, 2014 - Elsevier
Background Good catheter–tissue contact force (CF) is critical for transmural and durable
lesion formation during radiofrequency (RF) ablation but is difficult to assess in clinical practice…
lesion formation during radiofrequency (RF) ablation but is difficult to assess in clinical practice…
An electrocardiographic scoring system for distinguishing right ventricular outflow tract arrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy …
BACKGROUND: Ventricular arrhythmias in patients with arrhythmogenic right ventricular
dysplasia/cardiomyopathy (ARVD/C) and idiopathic ventricular tachycardia (VT) can share a …
dysplasia/cardiomyopathy (ARVD/C) and idiopathic ventricular tachycardia (VT) can share a …