To examine whether a capacitative Ca 2+ entry pathway is present in skeletal muscle, thin
muscle fibre bundles were isolated from extensor digitorum longus (EDL) muscle of adult mice…

Ryanodine receptors (RyRs) are huge homotetrameric Ca 2+ release channels localized to
the sarcoplasmic reticulum. RyRs are responsible for the release of Ca 2+ from the SR …

Three genomically distinct isoforms of RyR are now known. RyR1 homologue is the primary
isoform in skeletal muscles, whereas in cardiac muscles it is RyR2 homologue. RyR3 …

The ryanodine receptor (RyR) is a Ca 2+ release channel in the sarcoplasmic reticulum in
vertebrate skeletal muscle and plays an important role in excitation–contraction (E–C) …

Mobilization of intracellular Ca 2+ stores regulates a multitude of cellular functions, but the
role of intracellular Ca 2+ release via the ryanodine receptor (RyR) in the brain remains …

In this study, we investigated the effects of a short‐term and long‐term high‐fat diet ( HFD ) on
morphological and functional features of fast‐twitch skeletal muscle. Male C57 BL /6J mice …

Fura red, a fluorescent Ca2+ indicator with absorbance bands at visible wavelengths, was
injected into intact single muscle fibers that had been stretched to a long sarcomere length (…

Background Ventricular fibrillation may be caused by premature ventricular contractions (PVCs)
whose coupling intervals are <300 ms, a characteristic of the short-coupled variant of …

Mutations in ryanodine receptors (RyRs), intracellular Ca 2+ channels, are associated with
deadly disorders. Despite abundant functional studies, the molecular mechanism of RyR …

Hereditary deafness affects approximately 1 in 2,000 children. Mutations in the gene encoding
the cochlear gap junction protein connexin 26 (CX26) cause prelingual, nonsyndromic …