User profiles for Naincy R. Chandan
 | Naincy ChandanScientist III, Genentech Verified email at umich.edu Cited by 25 |
A network of Gαi signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF
NR Chandan, S Abraham, S SenGupta, CA Parent… - Science …, 2022 - science.org
G protein–coupled receptors (GPCRs) that couple to the Gα i family of G proteins are key
regulators of cell and tissue physiology. Our previous work has revealed new roles for Gα i in …
regulators of cell and tissue physiology. Our previous work has revealed new roles for Gα i in …
Discovery of small molecules that target the Phosphatidylinositol (3, 4, 5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P …
Phosphatidylinositol (3,4,5) trisphosphate (PIP 3 )-dependent Rac exchanger 1 (P-Rex1) is
a Rho guanine-nucleotide exchange factor that was originally discovered in neutrophils and …
a Rho guanine-nucleotide exchange factor that was originally discovered in neutrophils and …
[HTML][HTML] Stabilization of Interdomain Interactions in G protein α Subunits as a Determinant of Gαi Subtype Signaling Specificity
…, E Mukhaleva, SPM Venkata, NR Chandan… - Journal of Biological …, 2024 - Elsevier
Highly homologous members of the Gα i family, Gα i1-3 , have distinct tissue distributions and
physiological functions, yet their biochemical and functional properties are very similar. We …
physiological functions, yet their biochemical and functional properties are very similar. We …
Signaling, Physiology, and Targeting of GPCR‐Regulated Phospholipase C Enzymes
NR Chandan, AV Smrcka… - GPCRs as Therapeutic …, 2022 - Wiley Online Library
The phosphoinositide‐specific phospholipase C (PLC) enzyme family consists of six classes
of proteins that hydrolyze membrane phosphoinositides in response to various stimuli. …
of proteins that hydrolyze membrane phosphoinositides in response to various stimuli. …
Identification of G Protein αi Signaling Partners by Proximity Labeling Reveals a Network of Interactions that Includes PDZ-RhoGEF
NR Chandan, S Abraham, S SenGupta, CA Parent… - bioRxiv, 2021 - biorxiv.org
G protein-coupled receptors (GPCRs) that couple to the Gi family of G proteins are key
regulators of cell and tissue physiology. Our recent work has discovered novel roles for Gα i in …
regulators of cell and tissue physiology. Our recent work has discovered novel roles for Gα i in …
SMARCD3: A Link Between G?? q and Chromatin Remodeling?
J Loomis, NR Chandan, AV Smrcka - 2023 - ASPET
ID 21607 Poster Board 484 The G protein alpha subunit G?? q is a critical mediator of cells’
response to a variety of external stimuli as a result of activation of G q -coupled GPCRs. G?? …
response to a variety of external stimuli as a result of activation of G q -coupled GPCRs. G?? …
Identification of a sequence of the activity-dependent neuroprotective protein (ADNP) that is necessary for its interaction with G?? i1
ID 16245 Poster Board 328 The activity-dependent neuroprotective protein (ADNP) is crucial
for the proper development and maturation of the brain. A number of reports have shown its …
for the proper development and maturation of the brain. A number of reports have shown its …
Identifying Novel Signaling Mechanisms Downstream of Gq‐Coupled Receptors
JF Loomis, NR Chandan, MJ Brody… - The FASEB …, 2022 - Wiley Online Library
The G protein alpha subunit G□ q is a critical mediator of cells’ response to a variety of
external stimuli as a result of activation of G q ‐coupled GPCRs. G□ q ‐dependent signaling …
external stimuli as a result of activation of G q ‐coupled GPCRs. G□ q ‐dependent signaling …
Identification of PDZ‐RhoGEF as a Novel Target of Gαi Signaling
NR Chandan, S Abraham, AV Smrcka - The FASEB Journal, 2020 - Wiley Online Library
Cell‐migration and adhesion are fundamental biological processes regulated by chemokine
G‐protein‐coupled receptors (GPCRs). GPCRs bind to heterotrimeric G proteins, which are …
G‐protein‐coupled receptors (GPCRs). GPCRs bind to heterotrimeric G proteins, which are …
Identification and Characterization of G Protein Signaling Networks by Proximity Labeling-Coupled Proteomics
NR Chandan - 2021 - deepblue.lib.umich.edu
… I would like to express my utmost gratitude to my parents, Ramnik and Pratima Chandan, for
… I am very thankful to my younger brother and my most favorite person, Viral Chandan, who …
… I am very thankful to my younger brother and my most favorite person, Viral Chandan, who …