User profiles for Nanga. Ravi Prakash Reddy

Ravi Prakash Reddy Nanga, Ph.D., R.Ph.

Assistant Professor (Research Track), University of Pennsylvania
Verified email at pennmedicine.upenn.edu
Cited by 3945

Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI

M Haris, RPR Nanga, A Singh, K Cai… - NMR in …, 2012 - Wiley Online Library
Creatine (Cr), phosphocreatine (PCr) and adenosine‐5‐triphosphate (ATP) are major
metabolites of the enzyme creatine kinase (CK). The exchange rate of amine protons of CK …

[HTML][HTML] Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

RPR Nanga, JR Brender, S Vivekanandan… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Human islet amyloid polypeptide is a hormone coexpressed with insulin by pancreatic beta-cells.
For reasons not clearly understood, hIAPP aggregates in type II diabetics to form …

Role of zinc in human islet amyloid polypeptide aggregation

JR Brender, K Hartman, RPR Nanga… - Journal of the …, 2010 - ACS Publications
Human Islet Amyloid Polypeptide (hIAPP) is a highly amyloidogenic protein found in islet
cells of patients with type II diabetes. Because hIAPP is highly toxic to β-cells under certain …

Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy

KA Davis, RPR Nanga, S Das, SH Chen… - Science translational …, 2015 - science.org
When neuroimaging reveals a brain lesion, drug-resistant epilepsy patients show better
outcomes after resective surgery than do the one-third of drug-resistant epilepsy patients who …

Method for high‐resolution imaging of creatine in vivo using chemical exchange saturation transfer

…, RPR Nanga, H Hariharan, R Reddy - Magnetic resonance …, 2014 - Wiley Online Library
Purpose To develop a chemical exchange saturation transfer (CEST)‐based technique to
measure free creatine (Cr) and to validate the technique by measuring the distribution of Cr in …

Structures of Rat and Human Islet Amyloid Polypeptide IAPP1−19 in Micelles by NMR Spectroscopy

RPR Nanga, JR Brender, J Xu, G Veglia… - Biochemistry, 2008 - ACS Publications
Disruption of the cellular membrane by the amyloidogenic peptide IAPP (or amylin) has
been implicated in β-cell death during type 2 diabetes. While the structure of the mostly inert …

Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy

RPR Nanga, JR Brender, J Xu, K Hartman… - Journal of the …, 2009 - ACS Publications
Islet amyloid polypeptide (IAPP or amylin) is a 37-residue peptide hormone associated with
glucose metabolism that is cosecreted with insulin by β-cells in the pancreas. Since human …

Glutamate imaging (GluCEST) reveals lower brain GluCEST contrast in patients on the psychosis spectrum

DR Roalf, RPR Nanga, PE Rupert, H Hariharan… - Molecular …, 2017 - nature.com
Psychosis commonly develops in adolescence or early adulthood. Youths at clinical high
risk (CHR) for psychosis exhibit similar, subtle symptoms to those with schizophrenia (SZ). …

A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc

…, JR Brender, SJ Hyung, RPR Nanga… - Journal of molecular …, 2011 - Elsevier
Human islet amyloid polypeptide (hIAPP) is a highly amyloidogenic protein co-secreted with
insulin in response to glucose levels. The formation of hIAPP amyloid plaques near islet …

Mapping glutamate in subcortical brain structures using high‐resolution GluCEST MRI

K Cai, A Singh, DR Roalf, RPR Nanga… - NMR in …, 2013 - Wiley Online Library
In vivo measurement of glutamate (Glu) in brain subcortex can elucidate the role these
structures play in cognition and neuropsychiatric disorders. However, accurate quantification of …