User profiles for Nanga. Ravi Prakash Reddy
Ravi Prakash Reddy Nanga, Ph.D., R.Ph.Assistant Professor (Research Track), University of Pennsylvania Verified email at pennmedicine.upenn.edu Cited by 3945 |
Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI
Creatine (Cr), phosphocreatine (PCr) and adenosine‐5‐triphosphate (ATP) are major
metabolites of the enzyme creatine kinase (CK). The exchange rate of amine protons of CK …
metabolites of the enzyme creatine kinase (CK). The exchange rate of amine protons of CK …
[HTML][HTML] Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment
Human islet amyloid polypeptide is a hormone coexpressed with insulin by pancreatic beta-cells.
For reasons not clearly understood, hIAPP aggregates in type II diabetics to form …
For reasons not clearly understood, hIAPP aggregates in type II diabetics to form …
Role of zinc in human islet amyloid polypeptide aggregation
JR Brender, K Hartman, RPR Nanga… - Journal of the …, 2010 - ACS Publications
Human Islet Amyloid Polypeptide (hIAPP) is a highly amyloidogenic protein found in islet
cells of patients with type II diabetes. Because hIAPP is highly toxic to β-cells under certain …
cells of patients with type II diabetes. Because hIAPP is highly toxic to β-cells under certain …
Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy
When neuroimaging reveals a brain lesion, drug-resistant epilepsy patients show better
outcomes after resective surgery than do the one-third of drug-resistant epilepsy patients who …
outcomes after resective surgery than do the one-third of drug-resistant epilepsy patients who …
Method for high‐resolution imaging of creatine in vivo using chemical exchange saturation transfer
Purpose To develop a chemical exchange saturation transfer (CEST)‐based technique to
measure free creatine (Cr) and to validate the technique by measuring the distribution of Cr in …
measure free creatine (Cr) and to validate the technique by measuring the distribution of Cr in …
Structures of Rat and Human Islet Amyloid Polypeptide IAPP1−19 in Micelles by NMR Spectroscopy
Disruption of the cellular membrane by the amyloidogenic peptide IAPP (or amylin) has
been implicated in β-cell death during type 2 diabetes. While the structure of the mostly inert …
been implicated in β-cell death during type 2 diabetes. While the structure of the mostly inert …
Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy
Islet amyloid polypeptide (IAPP or amylin) is a 37-residue peptide hormone associated with
glucose metabolism that is cosecreted with insulin by β-cells in the pancreas. Since human …
glucose metabolism that is cosecreted with insulin by β-cells in the pancreas. Since human …
Glutamate imaging (GluCEST) reveals lower brain GluCEST contrast in patients on the psychosis spectrum
Psychosis commonly develops in adolescence or early adulthood. Youths at clinical high
risk (CHR) for psychosis exhibit similar, subtle symptoms to those with schizophrenia (SZ). …
risk (CHR) for psychosis exhibit similar, subtle symptoms to those with schizophrenia (SZ). …
A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc
Human islet amyloid polypeptide (hIAPP) is a highly amyloidogenic protein co-secreted with
insulin in response to glucose levels. The formation of hIAPP amyloid plaques near islet …
insulin in response to glucose levels. The formation of hIAPP amyloid plaques near islet …
Mapping glutamate in subcortical brain structures using high‐resolution GluCEST MRI
In vivo measurement of glutamate (Glu) in brain subcortex can elucidate the role these
structures play in cognition and neuropsychiatric disorders. However, accurate quantification of …
structures play in cognition and neuropsychiatric disorders. However, accurate quantification of …