C-myc contributes to malignancy of lung cancer: a potential anticancer drug target

P Chanvorachote, N Sriratanasak… - Anticancer …, 2020 - ar.iiarjournals.org
Emerging evidence has provided important information on oncoproteins involved in cancer
initiation, progression, metastasis, and resistance to current therapies. C-myc, one of the …

[HTML][HTML] 5-O-(N-Boc-l-Alanine)-Renieramycin T Induces Cancer Stem Cell Apoptosis via Targeting Akt Signaling

D Suksamai, S Racha, N Sriratanasak, C Chaotham… - Marine drugs, 2022 - mdpi.com
Cancer stem cells (CSCs) drive aggressiveness and metastasis by utilizing stem cell-related
signals. In this study, 5-O-(N-Boc-l-alanine)-renieramycin T (OBA-RT) was demonstrated to …

[HTML][HTML] Artonin f induces the ubiquitin-proteasomal degradation of c-met and decreases Akt-mTOR signaling

R Soonnarong, ID Putra, N Sriratanasak, B Sritularak… - Pharmaceuticals, 2022 - mdpi.com
Targeted therapies that selectively inhibit certain molecules in cancer cells have been
considered promising for cancer treatment. In lung cancer, evidence has suggested that …

[HTML][HTML] Artocarpin targets focal adhesion kinase-dependent epithelial to mesenchymal transition and suppresses migratory-associated integrins in lung cancer cells

N Nonpanya, K Sanookpan, N Sriratanasak… - Pharmaceutics, 2021 - mdpi.com
Focal adhesion kinase (FAK) controls several cancer aggressive potentials of cell movement
and dissemination. As epithelial–mesenchymal transition (EMT) and the migratory-…

[HTML][HTML] Cisplatin Induces Senescent Lung Cancer Cell-Mediated Stemness Induction via GRP78/Akt-Dependent Mechanism

N Sriratanasak, P Chunhacha, ZZ Ei, P Chanvorachote - Biomedicines, 2022 - mdpi.com
Cellular senescence is linked with chemotherapy resistance. Based on previous studies,
GRP78 is a signal transducer in senescent cells. However, the association between GRP78 …

[HTML][HTML] Hydroquinone 5-O-Cinnamoyl Ester of Renieramycin M Suppresses Lung Cancer Stem Cells by Targeting Akt and Destabilizes c-Myc

N Hongwiangchan, N Sriratanasak, D Wichadakul… - Pharmaceuticals, 2021 - mdpi.com
Cancer stem cells (CSCs) are distinct cancer populations with tumorigenic and self-renewal
abilities. CSCs are drivers of cancer initiation, progression, therapeutic failure, and disease …

Novel c-Myc–targeting compound N, N-Bis (5-ethyl-2-hydroxybenzyl) methylamine for mediated c-Myc ubiquitin-proteasomal degradation in lung cancer cells

N Sriratanasak, K Petsri, A Laobuthee… - Molecular …, 2020 - ASPET
Aberrant cellular Myc (c-Myc) is a common feature in the majority of human cancers and has
been linked to oncogenic malignancies. Here, we developed a novel c-Myc–targeting …

Standardized Thunbergia laurifolia Extract Inhibits PM2. 5-Induced Oxidative Stress by Regulating p62–KEAP1–NRF2 Signaling Pathway

B Jirabanjerdsiri, N Sriratanasak, P Towiwat… - in vivo, 2022 - iv.iiarjournals.org
Background/Aim: Fine particulate matter (PM 2.5 ) in air pollution causes skin damage
through the induction of oxidative stress in the epidermis. Antioxidants help counteract cellular …

Benzoxazine dimer analogue targets integrin β3 in lung cancer cells and suppresses anoikis resistance and migration

N Sriratanasak, N Nonpanya… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: Certain integrins including integrin β3 facilitate movement and survival of
metastatic cancer cells. We examined whether benzoxazine dimer analogue N,N-bis(5-ethyl-…

Analysis of Protein–Protein Interactions Identifies NECTIN2 as a Target of N, N-Bis (5-Ethyl-2-hydroxybenzyl) Methylamine for Inhibition of Lung Cancer Metastasis

…, K Petsri, S Roytrakul, N Sriratanasak… - Cancer Genomics & …, 2022 - cgp.iiarjournals.org
Background/Aim: Metastasis negatively affects the survival of lung cancer patients, however,
relatively few compounds have potential in metastasis suppression. This study investigated …