User profiles for Nicole L. Michmerhuizen
Nicole MichmerhuizenPostdoctoral Research Fellow, St. Jude Children's Research Hospital Verified email at stjude.org Cited by 637 |
Phase separation mediates NUP98 fusion oncoprotein leukemic transformation
We show that homotypic and heterotypic mechanisms of LLPS control NUP98–HOXA9
puncta formation, modulating transcriptional activity and transforming hematopoietic cells. …
puncta formation, modulating transcriptional activity and transforming hematopoietic cells. …
Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies
NL Michmerhuizen, JM Klco… - Blood, The Journal of …, 2020 - ashpublications.org
Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic
malignancies, particularly pediatric leukemias with poor patient outcomes. Although wild-type …
malignancies, particularly pediatric leukemias with poor patient outcomes. Although wild-type …
Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma
AC Birkeland, SK Foltin, NL Michmerhuizen, RC Hoesli… - Oral oncology, 2017 - Elsevier
Objective Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the
salivary glands. Tumor stage and grade have historically been important predictors of survival. …
salivary glands. Tumor stage and grade have historically been important predictors of survival. …
Proportion of CD4 and CD8 tumor infiltrating lymphocytes predicts survival in persistent/recurrent laryngeal squamous cell carcinoma
…, AJ Rosko, M Issa, KL Chow, NL Michmerhuizen… - Oral oncology, 2018 - Elsevier
Tumor infiltrating lymphocytes (TILs) have been shown to be an important prognostic factor
in patients with previously untreated head and neck cancer. After organ preservation therapy …
in patients with previously untreated head and neck cancer. After organ preservation therapy …
[HTML][HTML] Genetic determinants in head and neck squamous cell carcinoma and their influence on global personalized medicine
NL Michmerhuizen, AC Birkeland, CR Bradford… - Genes & …, 2016 - ncbi.nlm.nih.gov
While sequencing studies have provided an improved understanding of the genetic landscape
of head and neck squamous cell carcinomas (HNSCC), there remains a significant lack of …
of head and neck squamous cell carcinomas (HNSCC), there remains a significant lack of …
Identification of targetable ERBB2 aberrations in head and neck squamous cell carcinoma
…, SK Foltin, JE Mann, NL Michmerhuizen… - … –Head & Neck …, 2016 - jamanetwork.com
Importance ERBB2(formerlyHER2) is an important drug target in breast cancer, where anti-ERBB2
therapy has been shown to lead to improvements in disease recurrence and overall …
therapy has been shown to lead to improvements in disease recurrence and overall …
Comprehensive review of genetic factors contributing to head and neck squamous cell carcinoma development in low‐risk, nontraditional patients
MA Gingerich, JD Smith, NL Michmerhuizen… - Head & …, 2018 - Wiley Online Library
Background The past 2 decades have seen an increased incidence of head and neck squamous
cell carcinoma (HNSCC) in a nontraditional, low‐risk patient population (ie, ≤45 years …
cell carcinoma (HNSCC) in a nontraditional, low‐risk patient population (ie, ≤45 years …
The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines
Objectives We sought to describe the genetic complexity of 14 UM-SCC oral cavity cancer
cell lines that have remained uncharacterized despite being used as model systems for …
cell lines that have remained uncharacterized despite being used as model systems for …
Poly (amidoamine) dendrimer–methotrexate conjugates: the mechanism of interaction with folate binding protein
Generation 5 poly(amidoamine) (G5 PAMAM) methotrexate (MTX) conjugates employing
two small molecular linkers, G5-(COG-MTX) n , G5-(MFCO-MTX) n were prepared along with …
two small molecular linkers, G5-(COG-MTX) n , G5-(MFCO-MTX) n were prepared along with …
[HTML][HTML] Differential compensation mechanisms define resistance to PI3K inhibitors in PIK3CA amplified HNSCC
NL Michmerhuizen, E Leonard, A Kulkarni… - … -head and neck …, 2016 - ncbi.nlm.nih.gov
Objective Recent sequencing studies of head and neck squamous cell carcinomas (HNSCCs)
have identified the phosphatidylinositol 3-kinase (PI3K) pathway as the most frequently …
have identified the phosphatidylinositol 3-kinase (PI3K) pathway as the most frequently …