User profiles for Nicole L. Michmerhuizen

Nicole Michmerhuizen

Postdoctoral Research Fellow, St. Jude Children's Research Hospital
Verified email at stjude.org
Cited by 637

Phase separation mediates NUP98 fusion oncoprotein leukemic transformation

B Chandra, NL Michmerhuizen, HK Shirnekhi… - Cancer discovery, 2022 - AACR
We show that homotypic and heterotypic mechanisms of LLPS control NUP98–HOXA9
puncta formation, modulating transcriptional activity and transforming hematopoietic cells. …

Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies

NL Michmerhuizen, JM Klco… - Blood, The Journal of …, 2020 - ashpublications.org
Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic
malignancies, particularly pediatric leukemias with poor patient outcomes. Although wild-type …

Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma

AC Birkeland, SK Foltin, NL Michmerhuizen, RC Hoesli… - Oral oncology, 2017 - Elsevier
Objective Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the
salivary glands. Tumor stage and grade have historically been important predictors of survival. …

Proportion of CD4 and CD8 tumor infiltrating lymphocytes predicts survival in persistent/recurrent laryngeal squamous cell carcinoma

…, AJ Rosko, M Issa, KL Chow, NL Michmerhuizen… - Oral oncology, 2018 - Elsevier
Tumor infiltrating lymphocytes (TILs) have been shown to be an important prognostic factor
in patients with previously untreated head and neck cancer. After organ preservation therapy …

[HTML][HTML] Genetic determinants in head and neck squamous cell carcinoma and their influence on global personalized medicine

NL Michmerhuizen, AC Birkeland, CR Bradford… - Genes & …, 2016 - ncbi.nlm.nih.gov
While sequencing studies have provided an improved understanding of the genetic landscape
of head and neck squamous cell carcinomas (HNSCC), there remains a significant lack of …

Identification of targetable ERBB2 aberrations in head and neck squamous cell carcinoma

…, SK Foltin, JE Mann, NL Michmerhuizen… - … –Head & Neck …, 2016 - jamanetwork.com
Importance ERBB2(formerlyHER2) is an important drug target in breast cancer, where anti-ERBB2
therapy has been shown to lead to improvements in disease recurrence and overall …

Comprehensive review of genetic factors contributing to head and neck squamous cell carcinoma development in low‐risk, nontraditional patients

MA Gingerich, JD Smith, NL Michmerhuizen… - Head & …, 2018 - Wiley Online Library
Background The past 2 decades have seen an increased incidence of head and neck squamous
cell carcinoma (HNSCC) in a nontraditional, low‐risk patient population (ie, ≤45 years …

The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines

…, A Kulkarni, AC Birkeland, NL Michmerhuizen… - Oral oncology, 2018 - Elsevier
Objectives We sought to describe the genetic complexity of 14 UM-SCC oral cavity cancer
cell lines that have remained uncharacterized despite being used as model systems for …

Poly (amidoamine) dendrimer–methotrexate conjugates: the mechanism of interaction with folate binding protein

…, J Silpe, C Dougherty, NL Michmerhuizen… - Molecular …, 2014 - ACS Publications
Generation 5 poly(amidoamine) (G5 PAMAM) methotrexate (MTX) conjugates employing
two small molecular linkers, G5-(COG-MTX) n , G5-(MFCO-MTX) n were prepared along with …

[HTML][HTML] Differential compensation mechanisms define resistance to PI3K inhibitors in PIK3CA amplified HNSCC

NL Michmerhuizen, E Leonard, A Kulkarni… - … -head and neck …, 2016 - ncbi.nlm.nih.gov
Objective Recent sequencing studies of head and neck squamous cell carcinomas (HNSCCs)
have identified the phosphatidylinositol 3-kinase (PI3K) pathway as the most frequently …