Bacterial resistance to antibiotics: the role of biofilms
…, LG Garland, BD Hoyle, JW Costerton, N Seiler… - Progress in Drug …, 1991 - Springer
Bacteria adhere to natural and synthetic, medically important surfaces within an extracellular
polymer generically termed the glycocalyx. This quasi-structure is a biofilm. The enhanced …
polymer generically termed the glycocalyx. This quasi-structure is a biofilm. The enhanced …
Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells
…, B Duranton, L Badolo, F Gossé, C Bergmann, N Seiler… - Cancer letters, 2000 - Elsevier
Resveratrol, a natural polyphenolic phytoalexine present in grapes and wines, has been
reported to exert a variety of important pharmacological effects. We investigated the effects of …
reported to exert a variety of important pharmacological effects. We investigated the effects of …
Polyamines and apoptosis
N Seiler, F Raul - Journal of cellular and molecular medicine, 2005 - Wiley Online Library
The natural polyamines putrescine, spermidine and spermine are in multiple ways involved
in cell growth and the maintenance of cell viability. In the course of the last 15 years more …
in cell growth and the maintenance of cell viability. In the course of the last 15 years more …
Isosterism and bioisosterism in drug design
…, LG Garland, BD Hoyle, JW Costerton, N Seiler… - Progress in Drug …, 1991 - Springer
In every scientific undertaking that is to break new ground, one has to have a goal, a working
hypothesis, or a leading idea or fact. This will encourage research and help in the pursuit of …
hypothesis, or a leading idea or fact. This will encourage research and help in the pursuit of …
Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis
…, S Roussi, A Lobstein, B Fischer, N Seiler… - …, 2005 - academic.oup.com
Apples contain several classes of polyphenols: monomers (catechins, epicatechins) and
oligomers/polymers, such as the procyanidins. Our aim was (i) to study anti-proliferative …
oligomers/polymers, such as the procyanidins. Our aim was (i) to study anti-proliferative …
Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis
…, B Duranton, F Goss, R Schleiffer, N Seiler… - Nutrition and …, 2001 - Taylor & Francis
We studied the effect of oral administration of resveratrol, a natural constituent of grapes, on
tumorigenesis in Min mice. Min mice are congenic mice genetically predisposed to develop …
tumorigenesis in Min mice. Min mice are congenic mice genetically predisposed to develop …
Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 1. Selective enzyme inhibitors
N Seiler - Current drug targets, 2003 - ingentaconnect.com
As soon as the natural polyamines (PAs), putrescine (Put), spermidine (Spd) and spermine (Spm),
were recognized as ubiquitous constituents of eukaryotic cells, their involvement in …
were recognized as ubiquitous constituents of eukaryotic cells, their involvement in …
Polyamine metabolism
N Seiler - Digestion, 1990 - karger.com
Currently, two major pathways are distinguished along which the polyamines are metabolized:
the interconversion pathway and the so-called terminal polyamine catabo lism. In …
the interconversion pathway and the so-called terminal polyamine catabo lism. In …
Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 2. Structural analogues and derivatives
N Seiler - Current drug targets, 2003 - ingentaconnect.com
Owing to their role in growth-related processes the natural polyamines (PAs), putrescine (Put),
spermidine (Spd) and spermine (Spm) were identified about 30 years ago as potential …
spermidine (Spd) and spermine (Spm) were identified about 30 years ago as potential …
High-performance liquid chromatographic procedure for the simultaneous determination of the natural polyamines and their monoacetyl derivatives
N Seiler, B Knödgen - Journal of Chromatography B: Biomedical Sciences …, 1980 - Elsevier
The separation of the natural polyamines and their monoacetyl derivatives by high-performance
reversed-phase liquid chromatography is reported. Octane sulfonate was used to form …
reversed-phase liquid chromatography is reported. Octane sulfonate was used to form …