[PDF][PDF] The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

…, M Chiariello, JC Yu, H Teramoto, P Crespo, N Xu… - Cell, 1995 - cell.com
c-Jun amino-terminal kinases (JNKs) and mitogen-activatedprotein kinases (MAPKs) are
closely related; however, they are independently regulated by a variety of environmental stimuli…

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

P Crespo, N Xu, WF Simonds, JS Gutkind - Nature, 1994 - nature.com
MITOGEN-ACTIVATED protein kinases, MAP kinases or ERKs (extracellular signal-regulated
kinases) are rapidly stimulated by growth-promoting factors acting on a variety of cell-…

Protein SUMOylation modification and its associations with disease

…, Z Liang, G He, P Zhang, H Zhu, N Xu… - Open …, 2017 - royalsocietypublishing.org
SUMOylation, as a post-translational modification, plays essential roles in various biological
functions including cell growth, migration, cellular responses to stress and tumorigenesis. …

Mutated α subunit of the Gq protein induces malignant transformation in NIH 3T3 cells

G Kalinec, AJ Nazarali, S Hermouet, N Xu… - … and cellular biology, 1992 - Am Soc Microbiol
The discovery of mutated, GTPase-deficient α subunits of G s or G 12 in certain human
endocrine tumors has suggested that heterotrimeric G proteins play a role in the oncogenic …

The small GTP-binding protein Rho links G protein-coupled receptors and Gα12 to the serum response element and to cellular transformation

…, OA Coso, S Montaner, N Xu… - Proceedings of the …, 1997 - National Acad Sciences
Receptors coupled to heterotrimeric G proteins can effectively stimulate growth promoting
pathways in a large variety of cell types, and if persistently activated, these receptors can also …

Protecting the normal in order to better kill the cancer

B Liu, L Ezeogu, L Zellmer, B Yu, N Xu… - Cancer …, 2015 - Wiley Online Library
Chemotherapy is the only option for oncologists when a cancer has widely spread to different
body sites. However, almost all currently available chemotherapeutic drugs will eventually …

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.

N Xu, L Bradley, I Ambdukar… - Proceedings of the …, 1993 - National Acad Sciences
The discovery of GTPase-inhibiting mutations in genes for alpha subunits of Gs or G(i2) in
certain human endocrine tumors has raised the possibility that heterotrimeric guanine …

[HTML][HTML] Genomic heterogeneity of multiple synchronous lung cancer

…, S Zhang, L Chen, W Cai, L Li, M Shen, N Xu… - Nature …, 2016 - nature.com
Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual
tumours represent intrapulmonary metastases or independent tumours. In this study we …

[HTML][HTML] An approach to studying lung cancer-related proteins in human blood

…, H Zheng, M Gao, J He, S Shi, W Li, N Xu… - Molecular & cellular …, 2005 - ASBMB
Early stage lung cancer detection is the first step toward successful clinical therapy and
increased patient survival. Clinicians monitor cancer progression by profiling tumor cell proteins …

Proteomic characterization of two snake venoms: Naja naja atra and Agkistrodon halys

…, C Zhao, X Li, J Shao, J Yin, MB West, N Xu… - Biochemical …, 2004 - portlandpress.com
Snake venom is a complex mixture of proteins and peptides, and a number of studies have
described the biological properties of several venomous proteins. Nevertheless, a complete …