User profiles for Nino Zavradashvili

Nino Zavradashvili

research scientist at the institute of chemistry and molecular engineering, Agricultural …
Verified email at agruni.edu.ge
Cited by 172

Artificial polymers made of α-amino acids-poly (amino acid) s, pseudo-poly (amino acid) s, poly (depsipeptide) s, and pseudo-proteins

N Zavradashvili, J Puiggali… - Current pharmaceutical …, 2020 - ingentaconnect.com
Degradable polymers (DPs) - “green materials” of the future, have an innumerable use in
biomedicine, particularly in the fields of tissue engineering and drug delivery. Among these …

Library of cationic polymers composed of polyamines and arginine as gene transfection agents

N Zavradashvili, C Sarisozen, G Titvinidze… - Acs Omega, 2019 - ACS Publications
Combinatorially synthesized materials, especially cationic polymers (CPs), with gene
transfection function hold great promise in nanotechnology. However, the main limitations of the …

Arginine-based biodegradable ether–ester polymers with low cytotoxicity as potential gene carriers

T Memanishvili, N Zavradashvili, N Kupatadze… - …, 2014 - ACS Publications
The success of gene therapy depends on safe and effective gene carriers. Despite being
widely used, synthetic vectors based on poly(ethylenimine) (PEI), poly(l-lysine) (PLL), or poly(l-…

Oligoarginine peptides, a new family of nicotinic acetylcholine receptor inhibitors

…, M Zouridakis, R Katsarava, N Zavradashvili… - Molecular …, 2019 - ASPET
Many peptide ligands of nicotinic acetylcholine receptors (nAChRs) contain a large number
of positively charged amino acid residues, a striking example being conotoxins RgIA and …

Amino acid based epoxy-poly (ester amide) s—A new class of functional biodegradable polymers: Synthesis and chemical transformations

N Zavradashvili, G Jokhadze… - … Science, Part A, 2013 - Taylor & Francis
A new class of biodegradable functional polymers – epoxy-poly(ester amide)s (EPEAs), was
synthesized for the first time on the basis of naturally occurring α-amino acids, fatty diols …

Cell compatible arginine containing cationic polymer: one-pot synthesis and preliminary biological assessment

N Zavradashvili, T Memanishvili, N Kupatadze… - Infectious Diseases and …, 2014 - Springer
Synthetic cationic polymers are of interest as both nonviral vectors for intracellular gene delivery
and antimicrobial agents. For both applications synthetic polymers containing guanidine …

[HTML][HTML] New 1,2,3-Triazole Containing Polyesters via Click Step-Growth Polymerization and Nanoparticles Made of Them

…, G Otinashvili, N Kupatadze, N Zavradashvili… - International Journal of …, 2018 - hindawi.com
High-molecular-weight AA-BB-type aliphatic polyesters were synthesized via Cu(I)-catalyzed
click step-growth polymerization (SGP) following a new synthetic strategy. The synthesis …

Optically Active Polymers with Cationic Units Connected through Neutral Spacers: Helical Conformation and Chirality Transfer to External Molecules

Y Wang, N Zavradashvili, Y Wang, A Pietropaolo… - …, 2020 - ACS Publications
Cationic chiral polymers consisting of a chiral “Arg monomeric unit” consisting of two l-arginine
moieties joined together through an oxyhexane-1,6-diyloxy spacer unit and achiral “Sp …

New cationic polymers composed of non-proteinogenic α-amino acids

N Zavradashvili, G Otinashvili, T Kantaria… - Advanced Materials …, 2021 - taylorfrancis.com
The importance of cationic polymers (CPs) is universally recognized because they exhibit
unique biological properties; promote cell penetration of various molecules and nano-…

[PDF][PDF] Synthesis of Biomimetic Polymers Based on Nonproteinogenic α-Amino Acids

N Zavradashvili, G Otinashvili, D Tugushi… - Bull. Georg. Natl …, 2021 - researchgate.net
Materials and Methods Materials. 1, 6-hexanediol, p-toluenesulfonic acid monohydrate (TosOH.
H2O), cyclohexane, sebacic acid (SA), phosphorous pentachloride, dichloromethane (…