Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

…, S Loeber, PJ Halfmann, N Nakajima… - Proceedings of the …, 2020 - National Acad Sciences
At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2;
SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with …

[HTML][HTML] SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

…, B Whitener, J Moliva, K Floyd, M Ujie, N Nakajima… - Nature, 2022 - nature.com
The recent emergence of B.1.1.529, the Omicron variant 1 , 2 , has raised concerns of
escape from protection by vaccines and therapeutic antibodies. A key test for potential …

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

…, KH Dinnon III, SR Leist, A Schäfer, N Nakajima… - Science, 2020 - science.org
The spike aspartic acid–614 to glycine (D614G) substitution is prevalent in global severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral …

The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan

…, T Saito, K Fukushima, K Nakajima… - The Journal of …, 2014 - academic.oup.com
Background. Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS
virus (SFTSV), a novel bunyavirus reported to be endemic in central and northeastern China. …

[HTML][HTML] Characterization of H7N9 influenza A viruses isolated from humans

T Watanabe, M Kiso, S Fukuyama, N Nakajima, M Imai… - Nature, 2013 - nature.com
Avian influenza A viruses rarely infect humans; however, when human infection and subsequent
human-to-human transmission occurs, worldwide outbreaks (pandemics) can result. …

[PDF][PDF] Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling

…, H Kitani, K Ikejima, H Kirikoshi, N Nakajima… - Cell metabolism, 2012 - cell.com
Although bacterial endotoxin, such as lipopolysaccharide (LPS), plays a key role in the
pathogenesis of nonalcoholic steatohepatitis (NASH), detailed mechanisms of this pathogenesis …

[HTML][HTML] Identification of multispecific organic anion transporter 2 expressed predominantly in the liver

…, SH Cha, M Tsuda, N Apiwattanakul, N Nakajima… - FEBS letters, 1998 - Elsevier
In the present study, we demonstrate that NLT (novel liver-specific transport protein) is a
multispecific organic anion transporter of the liver. The amino acid sequence of NLT shows 42% …

Analysis of deaths during the severe acute respiratory syndrome (SARS) epidemic in Singapore: challenges in determining a SARS diagnosis

…, ES Teo, KB Tan, N Nakajima… - … of pathology & …, 2004 - meridian.allenpress.com
Context.—An outbreak of severe acute respiratory syndrome (SARS), an infectious disease
attributed to a novel coronavirus, occurred in Singapore during the first quarter of 2003 and …

[HTML][HTML] The SARS-CoV-2 B. 1.1. 529 Omicron virus causes attenuated infection and disease in mice and hamsters

…, B Ying, B Whitener, K Floyd, M Ujie, N Nakajima… - Research …, 2021 - ncbi.nlm.nih.gov
Despite the development and deployment of antibody and vaccine countermeasures, rapidly-spreading
SARS-CoV-2 variants with mutations at key antigenic sites in the spike protein …

Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury

A Nakajima, K Wada, H Miki, N Kubota, N Nakajima… - Gastroenterology, 2001 - Elsevier
Background & Aims: Peroxisome proliferator–activated receptor γ (PPARγ) is a nuclear
receptor whose activation has been linked to several physiologic pathways including those …