User profiles for Nour Al-Muhtasib
Nour Al-muhtasibYale University Verified email at yale.edu Cited by 171 |
Neonatal phenobarbital exposure disrupts GABA ergic synaptic maturation in rat CA 1 neurons
Objective Phenobarbital is the most commonly utilized drug for the treatment of neonatal
seizures. The use of phenobarbital continues despite growing evidence that it exerts suboptimal …
seizures. The use of phenobarbital continues despite growing evidence that it exerts suboptimal …
Differential electrophysiological properties of D1 and D2 spiny projection neurons in the mouse nucleus accumbens core
The striatum consists of the dorsal (caudate/putamen) and the ventral (nucleus accumbens)
regions. The nucleus accumbens is further divided into a core and shell. Both the dorsal and …
regions. The nucleus accumbens is further divided into a core and shell. Both the dorsal and …
Absolute configuration and pharmacology of the poison frog alkaloid phantasmidine
…, JL Yakel, TT Olson, N Al-Muhtasib… - Journal of natural …, 2018 - ACS Publications
Phantasmidine, a rigid congener of the well-known nicotinic acetylcholine receptor agonist
epibatidine, is found in the same species of poison frog (Epipedobates anthonyi). Natural …
epibatidine, is found in the same species of poison frog (Epipedobates anthonyi). Natural …
Chemistry and pharmacological studies of 3-alkoxy-2, 5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce …
Y Liu, J Richardson, T Tran, N Al-Muhtasib… - Journal of medicinal …, 2013 - ACS Publications
Neuronal acetylcholine receptors mediate the addictive effects of nicotine and may also be
involved in alcohol addiction. Varenicline, an approved smoking cessation medication, …
involved in alcohol addiction. Varenicline, an approved smoking cessation medication, …
Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands
…, AH Rezvani, T Tran, N Al-Muhtasib… - Journal of Medicinal …, 2013 - ACS Publications
Developing novel and selective compounds that desensitize α4β2 nicotinic acetylcholine
receptors (nAChRs) could provide new effective treatments for nicotine addiction, as well as …
receptors (nAChRs) could provide new effective treatments for nicotine addiction, as well as …
APOE genotype alters immunoglobulin subtypes in knock-in mice
Y Zhou, W Zhao, N Al-Muhtasib… - Journal of Alzheimer's …, 2015 - content.iospress.com
Apolipoprotein E (APOE) alleles are strongly related to the risk of Alzheimer’s disease (AD).
APOE genotype also affects inflammatory processes in response to damage. We tested …
APOE genotype also affects inflammatory processes in response to damage. We tested …
AT-1001 is a partial agonist with high affinity and selectivity at human and rat α3β4 nicotinic cholinergic receptors
…, TT Olson, Y Gao, CA Stockmeier, N Al-Muhtasib… - Molecular …, 2015 - ASPET
AT-1001 [N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1] nonan-3-amine] is a high-affinity
and highly selective ligand at α3β4 nicotinic cholinergic receptors (nAChRs) that was …
and highly selective ligand at α3β4 nicotinic cholinergic receptors (nAChRs) that was …
Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333
…, M Sako, M Chebib, T Tran, N Al-Muhtasib… - Bioorganic & medicinal …, 2012 - Elsevier
A series of ligands based on SEN12333, containing either contracted or elongated alkyl
chains, were synthesized and evaluated in molecular docking studies against a homology …
chains, were synthesized and evaluated in molecular docking studies against a homology …
Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A
Y Liu, M Paige, TT Olson, N Al-Muhtasib, T Xie… - Bioorganic & Medicinal …, 2014 - Elsevier
The enantiomers of two analogs of Sazetidine-A as well as several other novel biosteric
analogues were synthesized. Their binding affinities at three major nAChRs subtypes and …
analogues were synthesized. Their binding affinities at three major nAChRs subtypes and …
[HTML][HTML] MMP-1 overexpression selectively alters inhibition in D1 spiny projection neurons in the mouse nucleus accumbens core
Protease activated receptor-1 (PAR-1) and its ligand, matrix metalloproteinase-1 (MMP-1),
are altered in several neurodegenerative diseases. PAR-1/MMP-1 signaling impacts …
are altered in several neurodegenerative diseases. PAR-1/MMP-1 signaling impacts …