GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
S Jo, O Yarishkin, YJ Hwang, YE Chun, M Park… - Nature medicine, 2014 - nature.com
In Alzheimer's disease (AD), memory impairment is the most prominent feature that afflicts
patients and their families. Although reactive astrocytes have been observed around amyloid …
patients and their families. Although reactive astrocytes have been observed around amyloid …
TRPV4 and AQP4 channels synergistically regulate cell volume and calcium homeostasis in retinal Müller glia
Brain edema formation occurs after dysfunctional control of extracellular volume partly
through impaired astrocytic ion and water transport. Here, we show that such processes might …
through impaired astrocytic ion and water transport. Here, we show that such processes might …
[HTML][HTML] A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes
E Mi Hwang, E Kim, O Yarishkin, D Ho Woo… - Nature …, 2014 - nature.com
TWIK-1 is a member of the two-pore domain K + (K2P) channel family that plays an
essential part in the regulation of resting membrane potential and cellular excitability. The …
essential part in the regulation of resting membrane potential and cellular excitability. The …
Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease
Monoamine oxidase–B (MAO-B) has recently emerged as a potential therapeutic target for
Alzheimer’s disease (AD) because of its association with aberrant γ-aminobutyric acid (GABA…
Alzheimer’s disease (AD) because of its association with aberrant γ-aminobutyric acid (GABA…
[HTML][HTML] TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye
An intractable challenge in glaucoma treatment has been to identify druggable targets
within the conventional aqueous humor outflow pathway, which is thought to be regulated/…
within the conventional aqueous humor outflow pathway, which is thought to be regulated/…
Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow
O Yarishkin, TTT Phuong, JM Baumann… - The Journal of …, 2021 - Wiley Online Library
Key points Trabecular meshwork (TM) is a highly mechanosensitive tissue in the eye that
regulates intraocular pressure through the control of aqueous humour drainage. Its dysfunction …
regulates intraocular pressure through the control of aqueous humour drainage. Its dysfunction …
Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells
TTT Phuong, SN Redmon, O Yarishkin… - The Journal of …, 2017 - Wiley Online Library
Key points Endothelial cells employ transient receptor potential isoform 4 (TRPV4) channels
to sense ambient mechanical and chemical stimuli. In retinal microvascular endothelial cells…
to sense ambient mechanical and chemical stimuli. In retinal microvascular endothelial cells…
Sulfonate chalcone as new class voltage-dependent K+ channel blocker
OV Yarishkin, HW Ryu, JY Park, MS Yang… - Bioorganic & medicinal …, 2008 - Elsevier
Chalcone derivatives 1–17 were synthesized and their voltage-dependent K + channel
inhibitory activities were investigated. The effective K + channel blockers were shown to be …
inhibitory activities were investigated. The effective K + channel blockers were shown to be …
Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels
…, R Roberts, BA Berkowitz, O Yarishkin… - Proceedings of the …, 2016 - National Acad Sciences
Fluid secretion by the ciliary body plays a critical and irreplaceable function in vertebrate
vision by providing nutritive support to the cornea and lens, and by maintaining intraocular …
vision by providing nutritive support to the cornea and lens, and by maintaining intraocular …
TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells
Mechanotransduction by the trabecular meshwork (TM) is an essential component of intraocular
pressure regulation in the vertebrate eye. This process is compromised in glaucoma but …
pressure regulation in the vertebrate eye. This process is compromised in glaucoma but …