GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

S Jo, O Yarishkin, YJ Hwang, YE Chun, M Park… - Nature medicine, 2014 - nature.com
In Alzheimer's disease (AD), memory impairment is the most prominent feature that afflicts
patients and their families. Although reactive astrocytes have been observed around amyloid …

TRPV4 and AQP4 channels synergistically regulate cell volume and calcium homeostasis in retinal Müller glia

…, TTT Phuong, AS Verkman, O Yarishkin… - Journal of …, 2015 - Soc Neuroscience
Brain edema formation occurs after dysfunctional control of extracellular volume partly
through impaired astrocytic ion and water transport. Here, we show that such processes might …

[HTML][HTML] A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes

E Mi Hwang, E Kim, O Yarishkin, D Ho Woo… - Nature …, 2014 - nature.com
TWIK-1 is a member of the two-pore domain K + (K2P) channel family that plays an
essential part in the regulation of resting membrane potential and cellular excitability. The …

Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease

…, J Woo, H Chun, HJ Kim, SJ Shin, O Yarishkin… - Science …, 2019 - science.org
Monoamine oxidase–B (MAO-B) has recently emerged as a potential therapeutic target for
Alzheimer’s disease (AD) because of its association with aberrant γ-aminobutyric acid (GABA…

[HTML][HTML] TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

DA Ryskamp, AM Frye, TTT Phuong, O Yarishkin… - Scientific reports, 2016 - nature.com
An intractable challenge in glaucoma treatment has been to identify druggable targets
within the conventional aqueous humor outflow pathway, which is thought to be regulated/…

Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow

O Yarishkin, TTT Phuong, JM Baumann… - The Journal of …, 2021 - Wiley Online Library
Key points Trabecular meshwork (TM) is a highly mechanosensitive tissue in the eye that
regulates intraocular pressure through the control of aqueous humour drainage. Its dysfunction …

Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells

TTT Phuong, SN Redmon, O Yarishkin… - The Journal of …, 2017 - Wiley Online Library
Key points Endothelial cells employ transient receptor potential isoform 4 (TRPV4) channels
to sense ambient mechanical and chemical stimuli. In retinal microvascular endothelial cells…

Sulfonate chalcone as new class voltage-dependent K+ channel blocker

OV Yarishkin, HW Ryu, JY Park, MS Yang… - Bioorganic & medicinal …, 2008 - Elsevier
Chalcone derivatives 1–17 were synthesized and their voltage-dependent K + channel
inhibitory activities were investigated. The effective K + channel blockers were shown to be …

Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels

…, R Roberts, BA Berkowitz, O Yarishkin… - Proceedings of the …, 2016 - National Acad Sciences
Fluid secretion by the ciliary body plays a critical and irreplaceable function in vertebrate
vision by providing nutritive support to the cornea and lens, and by maintaining intraocular …

TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells

O Yarishkin, TTT Phuong, CA Bretz, KW Olsen… - Journal of General …, 2018 - rupress.org
Mechanotransduction by the trabecular meshwork (TM) is an essential component of intraocular
pressure regulation in the vertebrate eye. This process is compromised in glaucoma but …