X-ray or NMR structures of proteins are often derived without their ligands, and even when
the structure of a full complex is available, the area of contact that is functionally and …

Automated annotation of protein function is challenging. As the number of sequenced
genomes rapidly grows, the overwhelming majority of protein products can only be annotated …

Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome …

Rapid progress in structural biology and whole-genome sequencing technology means that,
for many protein families, structural and evolutionary information are readily available. …

Physiological effects of β adrenergic receptor (β2AR) stimulation have been classically shown
to result from G s -dependent adenylyl cyclase activation. Here we demonstrate a novel …

The lysosomal degradation pathway of autophagy has a crucial role in defence against
infection, neurodegenerative disorders, cancer and ageing. Accordingly, agents that induce …

The TP53 tumor suppressor gene is frequently mutated in human cancers. An analysis of five
data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome …

We screened 71 sporadic and 7 familial Rett syndrome (RTT) patients for MECP2 mutations
by direct sequencing and determined the pattern of X chromosome inactivation (XCI) in 39 …

Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global,
community-driven effort to evaluate and improve the computational annotation of protein …

A LARGE superfamily of receptors containing seven transmembrane (TM) helices transmits
hormonal and sensory signals across the plasma membrane to heterotrimeric G proteins at …