[HTML][HTML] Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor …

T Okada, Y Kawano, T Sakakibara, O Hazeki… - Journal of Biological …, 1994 - Elsevier
Significant activity of phosphatidylinositol 3-kinase (PI 3-kinase) was detected in the membrane
fractions, or in the immunoprecipitates prepared with anti-phosphotyrosine antibodies, …

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

M Ui, T Okada, K Hazeki, O Hazeki - Trends in biochemical sciences, 1995 - cell.com
Wortmannin is a fungal metabolite that so far has been shown to act as a selective inhibitor
of phosphoinositide 3-kinase. It can therefore be used to investigate the convergence …

A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4 …

M Ii, N Matsunaga, K Hazeki, K Nakamura… - Molecular …, 2006 - ASPET
Proinflammatory mediators such as cytokines and NO play pivotal roles in various inflammatory
diseases. To combat inflammatory diseases successfully, regulation of proinflammatory …

[HTML][HTML] Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide

…, S Hoshino, Y Fukui, M Ui, O Hazeki… - Journal of Biological …, 1997 - ASBMB
Phosphoinositide 3-kinase (PI 3-kinase) is a key signaling enzyme implicated in variety of
receptor-stimulated cell responses. Receptors with intrinsic or associated tyrosine kinase …

[HTML][HTML] Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

T Okada, L Sakuma, Y Fukui, O Hazeki, M Ui - Journal of Biological …, 1994 - Elsevier
Wortmannin, a fungal metabolite, inhibited 32P labeling of phosphatidylinositol trisphosphate,
a product of phosphatidylinositol 3-kinase (PI 3-kinase), selectively in formyl peptide-…

Role of phosphoinositide 3-kinase in innate immunity

K Hazeki, K Nigorikawa, O Hazeki - Biological and Pharmaceutical …, 2007 - jstage.jst.go.jp
Recent advances in our understanding of the molecular basis of mammalian host immune
responses to microbial invasion suggest that the first line of defense against microbes is the …

Noninvasive quantitative analysis of blood oxygenation in rat skeletal muscle

A Seiyama, O Hazeki, M Tamura - The Journal of Biochemistry, 1988 - academic.oup.com
Using the isolated perfused rat hindlimb and the fluorocarbon-transfused rat, we have examined
the optical characteristics of the rat skeletal muscle in the near-infrared region. The total …

Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells

…, R Kasai, K Hattori, S Takasuga, O Hazeki… - Planta …, 2002 - thieme-connect.com
Glucose transport enhancers were searched for in Lagerstroemia speciosa, a Philippine local
herbal medicine used for diabetes mellitus. Bioassay-guided fractionation of the aqueous …

Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.

…, K Hazeki, Y Fukui, T Seya, T Okada, O Hazeki… - Journal of Biological …, 1994 - Elsevier
… , Yasuhisa FukuiS, Tsukasa Seya§, Taro Okadan, Osamu Hazekin, … Okada, T., Kawano, Y.,
Sakakibara, T., Hazeki, O., and Ui, M. (… Kojima, A., Hazeki, K., and Seya, T. (1991) Scand. J. …

Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice

…, Y Saeki, T Akazawa, K Hazeki, O Hazeki… - Cancer …, 2009 - Wiley Online Library
Oral administration of hot‐water extract of Spirulina, cyanobacterium Spirulina platensis,
leads to augmentation of NK cytotoxicity in humans. Here, we applied to syngeneic tumor‐…