[HTML][HTML] Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor …
T Okada, Y Kawano, T Sakakibara, O Hazeki… - Journal of Biological …, 1994 - Elsevier
Significant activity of phosphatidylinositol 3-kinase (PI 3-kinase) was detected in the membrane
fractions, or in the immunoprecipitates prepared with anti-phosphotyrosine antibodies, …
fractions, or in the immunoprecipitates prepared with anti-phosphotyrosine antibodies, …
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
M Ui, T Okada, K Hazeki, O Hazeki - Trends in biochemical sciences, 1995 - cell.com
Wortmannin is a fungal metabolite that so far has been shown to act as a selective inhibitor
of phosphoinositide 3-kinase. It can therefore be used to investigate the convergence …
of phosphoinositide 3-kinase. It can therefore be used to investigate the convergence …
A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4 …
M Ii, N Matsunaga, K Hazeki, K Nakamura… - Molecular …, 2006 - ASPET
Proinflammatory mediators such as cytokines and NO play pivotal roles in various inflammatory
diseases. To combat inflammatory diseases successfully, regulation of proinflammatory …
diseases. To combat inflammatory diseases successfully, regulation of proinflammatory …
[HTML][HTML] Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide
…, S Hoshino, Y Fukui, M Ui, O Hazeki… - Journal of Biological …, 1997 - ASBMB
Phosphoinositide 3-kinase (PI 3-kinase) is a key signaling enzyme implicated in variety of
receptor-stimulated cell responses. Receptors with intrinsic or associated tyrosine kinase …
receptor-stimulated cell responses. Receptors with intrinsic or associated tyrosine kinase …
[HTML][HTML] Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.
T Okada, L Sakuma, Y Fukui, O Hazeki, M Ui - Journal of Biological …, 1994 - Elsevier
Wortmannin, a fungal metabolite, inhibited 32P labeling of phosphatidylinositol trisphosphate,
a product of phosphatidylinositol 3-kinase (PI 3-kinase), selectively in formyl peptide-…
a product of phosphatidylinositol 3-kinase (PI 3-kinase), selectively in formyl peptide-…
Role of phosphoinositide 3-kinase in innate immunity
K Hazeki, K Nigorikawa, O Hazeki - Biological and Pharmaceutical …, 2007 - jstage.jst.go.jp
Recent advances in our understanding of the molecular basis of mammalian host immune
responses to microbial invasion suggest that the first line of defense against microbes is the …
responses to microbial invasion suggest that the first line of defense against microbes is the …
Noninvasive quantitative analysis of blood oxygenation in rat skeletal muscle
A Seiyama, O Hazeki, M Tamura - The Journal of Biochemistry, 1988 - academic.oup.com
Using the isolated perfused rat hindlimb and the fluorocarbon-transfused rat, we have examined
the optical characteristics of the rat skeletal muscle in the near-infrared region. The total …
the optical characteristics of the rat skeletal muscle in the near-infrared region. The total …
Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells
…, R Kasai, K Hattori, S Takasuga, O Hazeki… - Planta …, 2002 - thieme-connect.com
Glucose transport enhancers were searched for in Lagerstroemia speciosa, a Philippine local
herbal medicine used for diabetes mellitus. Bioassay-guided fractionation of the aqueous …
herbal medicine used for diabetes mellitus. Bioassay-guided fractionation of the aqueous …
Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.
… , Yasuhisa FukuiS, Tsukasa Seya§, Taro Okadan, Osamu Hazekin, … Okada, T., Kawano, Y.,
Sakakibara, T., Hazeki, O., and Ui, M. (… Kojima, A., Hazeki, K., and Seya, T. (1991) Scand. J. …
Sakakibara, T., Hazeki, O., and Ui, M. (… Kojima, A., Hazeki, K., and Seya, T. (1991) Scand. J. …
Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice
…, Y Saeki, T Akazawa, K Hazeki, O Hazeki… - Cancer …, 2009 - Wiley Online Library
Oral administration of hot‐water extract of Spirulina, cyanobacterium Spirulina platensis,
leads to augmentation of NK cytotoxicity in humans. Here, we applied to syngeneic tumor‐…
leads to augmentation of NK cytotoxicity in humans. Here, we applied to syngeneic tumor‐…