Background— Cardiac ion channelopathies are responsible for an ever-increasing number
and diversity of familial cardiac arrhythmia syndromes. We describe a new clinical entity that …

Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart
disease. One of the most frequent and potentially life threatening disorders of DM-induced …

1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) is a newly discovered activator
of human ether-a-go-go-related gene (hERG) K + channels. Here, we characterize the effects …

BACKGROUND: Cardiac sodium channel β-subunit mutations have been associated with
several inherited cardiac arrhythmia syndromes. OBJECTIVE: To identify and characterize …

Diabetes is a chronic metabolic disease characterized by hyperglycemia in the absence of
treatment. Among the diabetes-associated complications, cardiovascular disease is the major …

Increase of deposits of amyloid β peptides in the extracellular matrix is landmark during
Alzheimer’s Disease (AD) due to the imbalance in the production vs. clearance. This …

In this work we have combined biochemical and electrophysiological approaches to explore
the modulation of rat ventricular transient outward K + current (I to ) by calmodulin kinase II (…

Calmodulin (CaM) is the principal Ca 2+ sensor in eukaryotic cells, orchestrating the activity
of hundreds of proteins. Disease causing mutations at any of the three genes that encode …

The electrophysiological behavior of the zebrafish heart is very similar to that of the human
heart. In fact, most of the genes that codify the channels and regulatory proteins required for …

Over the last years zebrafish has become a popular model in the study of cardiac physiology,
pathology and pharmacology. Recently, the application of the 3Rs regulation and the …