Major depressive disorder is a common, complex, and potentially life-threatening mental
disorder that imposes a severe social and economic burden worldwide. Over the years, …

Major depressive disorder is a complex disease implicating many brain circuitries. The clinical
symptomatology is inconsistent and heterogenous and the pathogenesis is a complicated …

Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …

Ubiquitin coding sequences were isolated from a human genomic library and two cDNA
libraries. One human ubiquitin gene consists of 2055 nucleotides and codes for a polyprotein …

From clinical studies it is known that recurrent depressive episodes associate with a
reduced hippocampal volume. Conversely, preclinical studies have shown that chronic …

Current antidepressants are clinically effective only after several weeks of administration. Here,
we show that serotonin 4 (5-HT 4 ) agonists reduce immobility in the forced swimming test…

The interaction of the S- and R-enantiomers (escitalopram and R-citalopram) of citalopram,
with high- and low-affinity binding sites in COS-1 cell membranes expressing human SERT (…

Major depressive disorder is a common and complex mental disorder with unknown etiology.
GABAergic dysfunction is likely to contribute to the pathophysiology since disrupted …

The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviours in
laboratory rats. The aim of the present study was to examine the effects of chronic stress on …

Susceptibility to stress plays a crucial role in the development of psychiatric disorders such
as unipolar depression and post-traumatic stress disorder. In the present study the chronic …