Reported predictions of human in vivo hepatic clearance from in vitro data have used a variety
of values for the scaling factors human microsomal protein (MPPGL) and hepatocellularity …

The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has
been reported to exhibit polymorphism among individual humans (Kleinbloesem, CH, van …

The organ distribution of microsomal cytochrome P 450 isoenzymes (P 450), microsomal
epoxide hydrolase (EH) and cytosolic glutathione-S-transferases was investigated by …

… Immunoinhibition experiments were carried out by preincubating 50 pmol of total P-450
in 375 pL of 0.1 M potassium phosphate buffer (pH 7.4) with various amounts of antibodies (IgG) …

"Anti-liver/kidney microsome" (anti-LKM) autoantibodies have been found in the serum of
patients with cryptogenic chronic hepatitis and with immunoallergic drug-induced hepatitis, …

Immune-related drug responses are one of the most common sources of idiosyncratic toxicity.
A number of organs may be the target of such reactions; however, this review concentrates …

Rat and human lung microsomal cytochrome P-450 (P-450) enzymes have been characterized
with regard to their catalytic activities towards several xenobiotic chemicals, including …

… These two anti-malarial drugs are lysosomotropic agent that accumulates in acidic organelles
such as endosomes and lysosomes and neutralizes their pH thereby inhibiting the activity …

Sera from patients with dihydralazine-induced hepatitis were shown to contain anti-liver
microsomal autoantibodies (anti-LM) by indirect immunofluorescence. These anti-LM antibodies …

… microsomes (0.05 nmol of cytochrome P450) or human liver microsomes (0.25 mg of
microsomal protein) were mixed with Tris buffer (0.15 M potassium chloride in 0.050 M Tris-HCl, pH …