Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: mechanism underlying greater toxicity?
…, JH Moran, A Radominska-Pandya, PL Prather - Life sciences, 2014 - Elsevier
K2 or Spice products are emerging drugs of abuse that contain synthetic cannabinoids (SCBs).
Although assumed by many teens and first time drug users to be a “safe” and “legal” …
Although assumed by many teens and first time drug users to be a “safe” and “legal” …
[HTML][HTML] Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?
KA Seely, PL Prather, LP James… - Molecular …, 2011 - ncbi.nlm.nih.gov
Marijuana has been used recreationally and medicinally for centuries. The principle
psychoactive component, Δ 9-tetrahydrocannabinol (Δ 9-THC), activates CB1 cannabinoid …
psychoactive component, Δ 9-tetrahydrocannabinol (Δ 9-THC), activates CB1 cannabinoid …
The K2/Spice phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products
LK Brents, PL Prather - Drug metabolism reviews, 2014 - Taylor & Francis
In 2008, the European Monitoring Center for Drugs and Drug Addiction (EMCDDA) detected
unregulated, psychoactive synthetic cannabinoids (SCBs) in purportedly all-natural herbal …
unregulated, psychoactive synthetic cannabinoids (SCBs) in purportedly all-natural herbal …
[HTML][HTML] Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
…, JH Moran, WE Fantegrossi, PL Prather - PloS one, 2011 - journals.plos.org
Background K2 products are synthetic cannabinoid-laced, marijuana-like drugs of abuse,
use of which is often associated with clinical symptoms atypical of marijuana use, including …
use of which is often associated with clinical symptoms atypical of marijuana use, including …
The CB2 cannabinoid agonist AM‐1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset
…, RL Reed, JP Crow, PL Prather - Journal of …, 2007 - Wiley Online Library
… At onset, mice initially place their weight on the toes and then quickly fall to full foot
placement (as opposed to healthy mice which walk and run on the hind toes); this ‘toe-to-heel’ …
placement (as opposed to healthy mice which walk and run on the hind toes); this ‘toe-to-heel’ …
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands
…, LP James, PF Hollenberg, PL Prather… - Drug metabolism and …, 2012 - ASPET
Abuse of synthetic cannabinoids (SCs), such as [1-naphthalenyl-(1-pentyl-1H-indol-3-yl]-methanone
(JWH-018) and [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone (…
(JWH-018) and [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone (…
Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral …
…, WE Fantegrossi, JH Moran, PL Prather - Biochemical …, 2012 - Elsevier
K2 and several similar purported “incense products” spiked with synthetic cannabinoids are
abused as cannabis substitutes. We hypothesized that metabolism of JWH-073, a prevalent …
abused as cannabis substitutes. We hypothesized that metabolism of JWH-073, a prevalent …
Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine
…, WD Wessinger, WE Fantegrossi, PL Prather… - Analytical …, 2011 - ACS Publications
“K2/SPICE” products are commonly laced with aminoalkylindole synthetic cannabinoids (ie,
JWH-018 and JWH-073) and are touted as “legal” marijuana substitutes. Here we validate a …
JWH-018 and JWH-073) and are touted as “legal” marijuana substitutes. Here we validate a …
[HTML][HTML] Activation of cannabinoid CB2 receptor–mediated AMPK/CREB pathway reduces cerebral ischemic injury
IY Choi, C Ju, AMAA Jalin, DI Lee, PL Prather… - The American journal of …, 2013 - Elsevier
The type 2 cannabinoid receptor (CB2R) was recently shown to mediate neuroprotection in
ischemic injury. However, the role of CB2Rs in the central nervous system, especially …
ischemic injury. However, the role of CB2Rs in the central nervous system, especially …
Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids
A Mazur, CF Lichti, PL Prather, AK Zielinska… - Drug Metabolism and …, 2009 - ASPET
Tetrahydrocannabinol (Δ 9 -THC), the primary psychoactive ingredient in marijuana, is
subject to cytochrome P450 oxidation and subsequent UDP-glucuronosyltransferase (UGT)-…
subject to cytochrome P450 oxidation and subsequent UDP-glucuronosyltransferase (UGT)-…