Role of CDK/cyclin complexes in transcription and RNA splicing

P Loyer, JH Trembley, R Katona, VJ Kidd, JM Lahti - Cellular signalling, 2005 - Elsevier
The production of mRNAs in all living organisms is an extremely complex process that
includes multiple catalytic activities such as transcription, capping, splicing, polyadenylation, …

[HTML][HTML] Overview of radiolabeled somatostatin analogs for cancer imaging and therapy

R Eychenne, C Bouvry, M Bourgeois, P Loyer… - Molecules, 2020 - mdpi.com
Identified in 1973, somatostatin (SST) is a cyclic hormone peptide with a short biological half-life.
Somatostatin receptors (SSTRs) are widely expressed in the whole body, with five …

Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression

P Loyer, JH Trembley - Seminars in cell & developmental biology, 2020 - Elsevier
… Then, a third group includes the more recently identified atypical Cyclins G, I, J, O, P and Y
and other proteins not named after the conventional Cyclin nomenclature, such as CABLES 1 …

The Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Cascade Activation Is a Key Signalling Pathway Involved in the Regulation of G1 …

…, G Zanninelli, M Bilodeau, P Loyer… - … and cellular biology, 1999 - Taylor & Francis
In this study, activation of the mitogen-activated protein kinase kinase (MEK)/extracellular
signal-regulated kinase (ERK) signalling pathway was analyzed in proliferating rat …

Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture.

Z Abdel-Razzak, P Loyer, A Fautrel, JC Gautier… - Molecular …, 1993 - ASPET
Cytokines are thought to cause the depression of cytochrome P-450 (CYP)-associated drug
metabolism in humans during inflammation and infection. We have examined the role of five …

[HTML][HTML] Growth factor dependence of progression through G1 and S phases of adult rat hepatocytes in vitro: evidence of a mitogen restriction point in mid-late G1

P Loyer, S Cariou, D Glaise, M Bilodeau… - Journal of Biological …, 1996 - Elsevier
… Kinase assays were performed in a mixture containing 10 μl of histone H1 (5 mg/ml, Sigma
type IIIS), 5 μl of [γ- 32 P]ATP (Amersham, 3000 Ci/mmol) and 20 μl of buffer C (Loyer et al. …

DNAX accessory molecule‐1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vγ9Vδ2 T cells

…, F Cabillic, G Le Friec, S Salot, P Loyer… - European journal of …, 2009 - Wiley Online Library
Human Vγ9Vδ2 T lymphocytes can be activated by nonpeptidic antigens such as the
mevalonate pathway‐derived isopentenyl pyrophosphate or synthetic phosphoantigen such as …

ILr1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages

T Gicquel, S Robert, P Loyer, T Victoni… - The FASEB …, 2015 - Wiley Online Library
… 2 sided, and the threshold for statistical significance was set to P , 0.05. … P , 0.001 compared
with control treatment. D) MDMs were stimulated … P , 0.05 compared with positive control. …

[HTML][HTML] Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection

P Loyer, JH Trembley, JA Grenet, A Busson… - Journal of Biological …, 2008 - ASBMB
Although it has been reported that cyclin L1α and L2α proteins interact with CDK11 p110 ,
the nature of the cyclin L transcripts, the formation of complexes between the five cyclin L and …

Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells

H Akhdar, P Loyer, C Rauch, A Corlu… - European journal of …, 2009 - Elsevier
Acquisition of drug resistance by cancer cells is attributed to various factors including alterations
in apoptotic pathways, enhanced expression of multidrug resistance-associated proteins…