1. Some properties of haemoglobin isolated from larval haemolymph of the dipterian family
Chironomidae are described in the light of the historical accumulation of our knowledge and …

Despite intensive studies, the molecular basis of the decline of protein degradation with age
still remains unresolved. It is suspected that the proteasome is one of the key factors …

… conditions for the 20S proteasomes (Gaczynska and Osmulski, unpublished observations). …
of a channel entrance (Gaczynska & Osmulski, unpublished observations; archaebacterial …

The proteasome has key roles in neuronal proteostasis, including the removal of misfolded
and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. …

Substrate-specific inhibition of the proteasome has been unachievable despite great interest
in proteasome inhibitors as drugs. Recent studies demonstrated that PR39, a natural proline…

The 26S proteasome is a multisubunit enzyme composed of a cylindrical catalytic core (20S)
and a regulatory particle (19S) that together perform the essential degradation of cellular …

Intrinsic conformational transitions contribute to the catalytic action of many enzymes. Here
we use a single-molecule approach to demonstrate how such transitions are linked to the …

Amyloid beta (Aβ) is implicated in Alzheimer's disease (AD) as an integral component of both
neural toxicity and plaque formation. Brains of the longest-lived rodents, naked mole-rats (…

Single-cell proteomic profiling of clinical samples may facilitate the optimal selection of novel
drug targets, interpretation of early-phase clinical trial data, and development of predictive …

The 20S proteasome is the main protease that directly targets intrinsically disordered proteins
(IDPs) for proteolytic degradation. Mutations, oxidative stress, or aging can induce the …