Excitatory amino acids as a final common pathway for neurologic disorders
SA Lipton, PA Rosenberg - New England Journal of Medicine, 1994 - Mass Medical Soc
In many neurologic disorders, injury to neurons may be caused at least in part by overstimulation
of receptors for excitatory amino acids, including glutamate and aspartate. These …
of receptors for excitatory amino acids, including glutamate and aspartate. These …
[HTML][HTML] Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration
…, A Schousboe, HS Waagepetersen, PA Rosenberg… - …, 2021 - Elsevier
Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …
glutamate is of paramount importance for normal brain function and relies on an intricate …
The developing oligodendrocyte: key cellular target in brain injury in the premature infant
…, HC Kinney, FE Jensen, PA Rosenberg - International Journal of …, 2011 - Elsevier
… Additionally, our findings in cultured pre-OLs by Rosenberg and co-workers show a deficit
in scavenging of hydrogen peroxide by glutathione peroxidase and catalase (Baud et al., …
in scavenging of hydrogen peroxide by glutathione peroxidase and catalase (Baud et al., …
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
Innate immunity is an evolutionarily ancient system that provides organisms with immediately
available defense mechanisms through recognition of pathogen-associated molecular …
available defense mechanisms through recognition of pathogen-associated molecular …
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models
…, M Orman, K Shimada, PA Rosenberg… - Journal of the …, 2014 - ACS Publications
Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell
death. We found that Fer-1 inhibited cell death in cellular models of Huntington’s disease (HD), …
death. We found that Fer-1 inhibited cell death in cellular models of Huntington’s disease (HD), …
The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS
…, PL Follett, FE Jensen, PA Rosenberg… - Journal of …, 2002 - Soc Neuroscience
The immediate or innate immune response is the first line of defense against diverse
microbial pathogens and requires the expression of recently discovered toll-like receptors (TLRs). …
microbial pathogens and requires the expression of recently discovered toll-like receptors (TLRs). …
Responses of immature permanent teeth with infected necrotic pulp tissue and apical periodontitis/abscess to revascularization procedures
…, CA Chen, F Tayebaty, PA Rosenberg… - International …, 2012 - Wiley Online Library
Chen MY‐H, Chen K‐L, Chen C‐A, Tayebaty F, Rosenberg PA, Lin LM. Responses of
immature permanent teeth with infected necrotic pulp tissue and apical periodontitis/abscess to …
immature permanent teeth with infected necrotic pulp tissue and apical periodontitis/abscess to …
Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion
SA Back, X Gan, Y Li, PA Rosenberg… - Journal of …, 1998 - Soc Neuroscience
Death of oligodendrocyte (OL) precursors can be triggered in vitro by cystine deprivation, a
form of oxidative stress that involves depletion of intracellular glutathione. We report here that …
form of oxidative stress that involves depletion of intracellular glutathione. We report here that …
Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention
A Oka, MJ Belliveau, PA Rosenberg… - Journal of …, 1993 - Soc Neuroscience
Periventricular white matter injury, the principal variety of brain injury of the human premature
infant, involves differentiating oligodendroglia. Nothing is known of the biochemical …
infant, involves differentiating oligodendroglia. Nothing is known of the biochemical …
Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia
…, I Sung, LI Swzeda, PA Rosenberg… - … of Neuropathology & …, 2003 - academic.oup.com
Periventricular leukomalacia (PVL), the major substrate of cerebral palsy in survivors of
prematurity, is defined as focal periventricular necrosis and diffuse gliosis in immature cerebral …
prematurity, is defined as focal periventricular necrosis and diffuse gliosis in immature cerebral …