Protein microarrays, one emerging class of proteomic technologies, have broad applications
for discovery and quantitative analysis. A rapidly expanding use of this technology is the …

We have developed a general strategy and a versatile computer program for analysis of
data from ligand-binding experiments (eg, radioreceptor assay systems for hormones, …

Physiological and pharmacological studies of hormones, drugs, and neurotransmitters often
generate families of sigmoidal dose-response curves. Optimally efficient data analysis …

Mapping tumor cell protein networks in vivo will be critical for realizing the promise of patient-tailored
molecular therapy. Cancer can be defined as a dysregulation or hyperactivity in the …

Both stress-system activation and melancholic depression are characterized by fear,
constricted affect, stereotyped thinking, and similar changes in autonomic and neuroendocrine …

Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …

Because most potential molecular markers and targets are proteins, proteomic profiling is
expected to yield more direct answers to functional and pharmacological questions than does …

Cancer cells frequently have disease-specific chromosome rearrangements 1 , 2 , 3 , 4 . It is
poorly understood why translocations between chromosomes recur at specific breakpoints …

Retinal pigment epithelium (RPE) is a polarized cell layer critical for photoreceptor function
and survival. The unique physiology and relationship to the photoreceptors make the RPE a …