[PDF][PDF] Effects of the ferrous chelate of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ-1) on the kinetics of reduction of CDP by ribonucleotide …
PJ PREIDECKER, KC AGRAWAL… - Molecular …, 1980 - Citeseer
PREIDECKER, PJ, KC AGRAWAL, AC SARTORELLI AND EC MOORE. Effects of the ferrous
chelate of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ-1) on the …
chelate of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ-1) on the …
Inhibition of ribonucleotide reductase by α-(N)-heterocyclic carboxaldehyde thiosemicarbazones
EC Moore, AC Sartorelli - Pharmacology & therapeutics, 1984 - Elsevier
Ribonucleotide reductase (ribonucleoside diphosphate reductase, EC 1.17. 4.1), whose
structure, reaction mechanism and regulation have been recently reviewed (Thelander and …
structure, reaction mechanism and regulation have been recently reviewed (Thelander and …
Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in …
JG Cory, AH Cory, G Rappa, A Lorico, MC Llu… - Advances in enzyme …, 1995 - Elsevier
The synthesis of a new series of pyridine-2-carboxaldehyde thiosemicarbazones (HCTs) that
have amino groups in the 3- and 5-positions has allowed the comparison of the structure/…
have amino groups in the 3- and 5-positions has allowed the comparison of the structure/…
Herpes simplex type 1 ribonucleotide reductase. Mechanism studies with inhibitors.
T Spector, TE Jones - Journal of Biological Chemistry, 1985 - ASBMB
Several known inhibitors of mammalian ribonucleotide reductase were studied for their
interactions with herpes simplex virus type 1 (HSV-1) ribonucleotide reductase. MAIQ (4-methyl-5…
interactions with herpes simplex virus type 1 (HSV-1) ribonucleotide reductase. MAIQ (4-methyl-5…
Inhibitors of ribonucleotide reductase: Comparative effects of amino-and hydroxy-substituted pyridine-2-carboxaldehydethiosemicarbazones
JG Cory, AH Cory, G Rappa, A Lorico… - Biochemical …, 1994 - Elsevier
… ; at higher concentrations of 3-AP and agreement with the conclusions of Preidecker, et al. …
Preidecker PJ , Agrawal KC, Sartorelli AC and Moore EC, Effects of the ferrous chelate of 4-…
Preidecker PJ , Agrawal KC, Sartorelli AC and Moore EC, Effects of the ferrous chelate of 4-…
A Ferrous-Triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase
J Shao, B Zhou, AJ Di Bilio, L Zhu, T Wang, C Qi… - Molecular cancer …, 2006 - AACR
Ribonucleotide reductase plays a central role in cell proliferation by supplying deoxyribonucleotide
precursors for DNA synthesis and repair. The holoenzyme is a protein tetramer that …
precursors for DNA synthesis and repair. The holoenzyme is a protein tetramer that …
Herpes simplex virus type 1 ribonucleotide reductase: selective and synergistic inactivation by A1110U and its iron complex
DJT Porter, JA Harrington, T Spector - Biochemical pharmacology, 1990 - Elsevier
2-Acetylpyridine-5-[(dimethylamino)thiocarbonyl]thiocarbonohydrazone (A1110U)
inactivated herpes simplex virus Type 1 ribonucleotide reductase (EC 1.17.4.1) by a first-order …
inactivated herpes simplex virus Type 1 ribonucleotide reductase (EC 1.17.4.1) by a first-order …
Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. Destruction of the tyrosine free radical …
L Thelander, A Gräslund - Journal of Biological Chemistry, 1983 - Elsevier
The iron chelate of 1-formylisoquinoline thiosemicarbazone is one of the most potent inhibitors
known for mammalian ribonucleotide reductase. In this study, we show that the target for …
known for mammalian ribonucleotide reductase. In this study, we show that the target for …
[PDF][PDF] Modeling and proposed mechanism of two radical scavengers through docking to curtail the action of ribonucleotide reductase
S Natarajan, R Mathews - Journal of Biophysics and …, 2011 - academicjournals.org
Ribonucleotide reductase (RR) is a ubiquitous cytosolic enzyme required for DNA synthesis
and repair in all living cells. Therefore, the crucial role of this enzyme in cell division makes …
and repair in all living cells. Therefore, the crucial role of this enzyme in cell division makes …
Synthesis, Cytotoxicity, and Antitumor Activity of Copper(II) and Iron(II) Complexes of 4N-Azabicyclo[3.2.2]nonane Thiosemicarbazones Derived from Acyl Diazines
J Easmon, G Pürstinger, G Heinisch… - Journal of medicinal …, 2001 - ACS Publications
A series of thiosemicarbazones (TSCs) (bearing a 4 N-azabicyclo[3.2.2]nonane moiety)
derived from 3-acylpyridazines, 4-acetylpyrimidines, and 2-acetylpyrazines (1−8) were …
derived from 3-acylpyridazines, 4-acetylpyrimidines, and 2-acetylpyrazines (1−8) were …