User profiles for P. K. Karla
Pradeep Karlahoward university Verified email at howard.edu Cited by 902 |
[HTML][HTML] Ocular drug delivery barriers—role of nanocarriers in the treatment of anterior segment ocular diseases
… Karla contributed to the writing of barriers in anterior segment delivery section and supervised
the work. Sai HS Boddu conceived the project and provided advice and expert assistance …
the work. Sai HS Boddu conceived the project and provided advice and expert assistance …
[HTML][HTML] Polyamide/poly (amino acid) polymers for drug delivery
… The PK studies showed a longer circulation time in the blood for NC-6004 with a linear
pharmacokinetic profile. This shows an inferior cisplatin-related toxicity and superior anti-tumor …
pharmacokinetic profile. This shows an inferior cisplatin-related toxicity and superior anti-tumor …
Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular …
…, D Breuer, DB Lovejoy, DS Kalinowski, PK Karla… - Molecular …, 2011 - ASPET
HIV-1 transcription is activated by HIV-1 Tat protein, which recruits cyclin-dependent kinase
9 (CDK9)/cyclin T1 and other host transcriptional coactivators to the HIV-1 promoter. Tat itself …
9 (CDK9)/cyclin T1 and other host transcriptional coactivators to the HIV-1 promoter. Tat itself …
Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells
Purpose: Breast Cancer Resistance Protein (BCRP) belongs to the family of efflux transporters
involved in drug efflux leading to drug resistance. The objective of this study was to …
involved in drug efflux leading to drug resistance. The objective of this study was to …
Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux
PK Karla, TL Quinn, BL Herndon, P Thomas… - Journal of ocular …, 2009 - liebertpub.com
… 5 Karla PKPal D.Mitra AKMolecular evidence and functional expression of multidrug … 24
Karla PKPal D.Mitra AKMolecular evidence and functional expression of multi drug resistance-…
Karla PKPal D.Mitra AKMolecular evidence and functional expression of multi drug resistance-…
Novel nanoparticulate gel formulations of steroids for the treatment of macular edema
Purpose: This article describes the development and characterization of PLGA nanoparticles
of dexamethasone (DEX), hydrocortisone acetate (HA), and prednisolone acetate (PA) …
of dexamethasone (DEX), hydrocortisone acetate (HA), and prednisolone acetate (PA) …
Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux
Cornea is considered as a major barrier for ocular drug delivery. Low ocular bioavailability
of drugs has been attributed primarily to low permeability across corneal epithelium, thus …
of drugs has been attributed primarily to low permeability across corneal epithelium, thus …
Molecular evidence and functional expression of multidrug resistance associated protein (MRP) in rabbit corneal epithelial cells
Multidrug resistance associated protein (MRP) is a major family of efflux transporters involved
in drug efflux leading to drug resistance. The objective of this study was to explore physical …
in drug efflux leading to drug resistance. The objective of this study was to explore physical …
Development of a sensitive HPLC method to measure in vitro permeability of E-and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers
In the current study, we developed a HPLC method to quantitatively measure the permeability
of the BpT-based chelators, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT) and 2…
of the BpT-based chelators, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT) and 2…
The functional role of C-reactive protein in aortic wall calcification
As an ongoing effort to elucidate the mechanisms involved in bioprosthetic heart valve (BHV)
calcification, the role of C-reactive protein (CRP) in the tissue calcification process was …
calcification, the role of C-reactive protein (CRP) in the tissue calcification process was …