… sought to introduce an amino group in place of the hydroxyl group in position 7. In this manner,
it would have been possible to synthesize rapidly a number of derivatives using activated …

Despite significant advances in pharmacologic therapy of depression over the past two
decades, a substantial proportion of patients fail to respond or experience only partial response …

In the present study, we performed a systematic review and meta-analysis on published
data to examine the impact of CYP3A5 6986A> G and ABCB1 3435C> T polymorphisms on …

Aggregates of β‐amyloid peptide (βAP), the main constituent of amyloid plaques in Alzheimer's
brain, kill neurons by a not yet defined mechanism, leading to apoptotic death. Here, we …

… Short-term spatial memory was evaluated in the place recognition test by testing the ability
of the mice to discriminate a familiar versus a novel environment. The Y-maze was placed in a …

Aim: In the present study we conducted a systematic review and meta-analysis of published
data to quantify the impact of the DPYD IVS14+1G>A and 2846A>T variants on the risk of …

The amyloid hypothesis of Alzheimer's disease (AD) suggests that soluble amyloid β (Aβ) is
an initiator of a cascade of events eventually leading to neurodegeneration. Recently, we …

The effect of L‐glutamate (Glu) on human lymphocyte function was studied by measuring
anti‐CD 3 monoclonal antibody (mAb) or phytohaemagglutinin (PHA)‐induced intracellular Ca …

… The profile of changes in mRNA levels matched that of changes in protein (western blots),
although the mRNA changes took place at earlier times of exposure to HDAC inhibitors (…

… In a set of unpublished data, we also synthesized a compound bearing a sulfonamide
group (5) in place of the amide moiety of 1 (Figure 1). The sulfonamide should theoretically be …