Oxidative stress and beta-cell dysfunction

G Drews, P Krippeit-Drews, M Düfer - Pflügers Archiv-European Journal of …, 2010 - Springer
… correlated with enhanced expression of NAD(P)H oxidase [62]. Thus, ROS formation by NAD(…
by inhibition of ATP production in accordance with the findings of Krippeit-Drews et al. [39]. …

Electrophysiology of islet cells

G Drews, P Krippeit-Drews, M Düfer - The islets of langerhans, 2010 - Springer
… Depolarization-induced exocytosis is markedly suppressed by the P/Q-type blocker omega-…
impairs glucose tolerance (Düfer, Krippeit-Drews, Ruth, Drews, unpublished observation). …

[HTML][HTML] ABCC8 and ABCC9: ABC transporters that regulate K+ channels

…, X Zhang, M Düfer, G Drews, P Krippeit-Drews… - … -European Journal of …, 2007 - Springer
The sulfonylurea receptors (SURs) ABCC8/SUR1 and ABCC9/SUR2 are members of the C-branch
of the transport adenosine triphosphatase superfamily. Unlike their brethren, the …

Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel–deficient mice

…, K Essin, CA Sailer, U Abdullah, P Krippeit-Drews… - Circulation, 2005 - Am Heart Assoc
Background— Abnormally elevated blood pressure is the most prevalent risk factor for
cardiovascular disease. The large-conductance, voltage- and Ca 2+ -dependent K + (BK) channel …

Bile Acids Acutely Stimulate Insulin Secretion of Mouse β-Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition

…, R Lukowski, FJ Gonzalez, P Krippeit-Drews… - Diabetes, 2012 - Am Diabetes Assoc
Type 2 diabetes mellitus is associated with alterations in bile acid (BA) signaling. The aim of
our study was to test whether pancreatic β-cells contribute to BA-dependent regulation of …

Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells

P Krippeit-Drews, M Düfer, G Drews - Biochemical and biophysical …, 2000 - Elsevier
… , however, only resulted in a transient increase in NAD(P)H (14). Also for B-cells an increase
in dehydrogenases (15) and in NAD(P)H as a response to a glucose-evoked elevation in […

Expression pattern of aquaporin water channels in the inner ear of the rat: the molecular basis for a water regulation system in the endolymphatic sac

E Beitz, H Kumagami, P Krippeit-Drews… - Hearing research, 1999 - Elsevier
Mammalian aquaporins constitute a family of so far 10 related water channel proteins which
mediate osmotically driven water fluxes across the plasma membrane. Because regulation …

[HTML][HTML] Suppression of KATP channel activity protects murine pancreatic β cells against oxidative stress

B Gier, P Krippeit-Drews, T Sheiko… - The Journal of …, 2009 - Am Soc Clin Investig
The enhanced oxidative stress associated with type 2 diabetes mellitus contributes to disease
pathogenesis. We previously identified plasma membrane–associated ATP-sensitive K + (…

[HTML][HTML] Interference of H2O2 with stimulus-secretion coupling in mouse pancreatic β-cells

P Krippeit-Drews, C Krämer, S Welker… - The Journal of …, 1999 - ncbi.nlm.nih.gov
… In a previous paper we showed that H 2 O 2 hyperpolarizes the cell membrane and we
assumed that an intracellular factor is involved in this effect (Krippeit-Drews et al. 1994b). In the …

Enhanced glucose tolerance by SK4 channel inhibition in pancreatic β-cells

…, B Gier, D Wolpers, P Krippeit-Drews, P Ruth… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Ca 2+ -regulated K + channels are involved in numerous Ca 2+ -dependent
signaling pathways. In this study, we investigated whether the Ca 2+ -activated K + channel of …