Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

…, D Rico, J Aragonés, P Martin-Sanz… - The Journal of …, 2010 - journals.aai.org
Macrophages play a relevant role in innate and adaptive immunity depending on the
balance of the stimuli received. From an analytical and functional point of view, macrophage …

[HTML][HTML] Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

…, L Boscá, C García-Monzón, P Martín-Sanz… - Cell death & …, 2014 - nature.com
The pathogenic mechanisms underlying the progression of non-alcoholic fatty liver disease (NAFLD)
are not fully understood. In this study, we aimed to assess the relationship between …

Inhibition of IκB Kinase and IκB Phosphorylation by 15-Deoxy-Δ12,14-Prostaglandin J2 in Activated Murine Macrophages

…, S Hortelano, P Martín-Sanz… - … and Cellular Biology, 2000 - Taylor & Francis
Activation of the macrophage cell line RAW 264.7 with lipopolysaccharide (LPS) and
gamma interferon (IFN-γ) induces the expression of gene products involved in host defense, …

HIF-1α and PFKFB3 mediate a tight relationship between proinflammatory activation and anerobic metabolism in atherosclerotic macrophages

…, R Bartrons, P Martín-Sanz… - … , and vascular biology, 2015 - Am Heart Assoc
P<0.05; ##P<0.01 vs the same O 2 in the absence of LDL or oxLDL (A and B); *P<0.05; **P<0.01
vs the same condition under normoxia (A–C), vs the same condition in the absence of …

Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in …

…, G Clemente, C Garcia-Monzon, P Martin-Sanz - Gut, 2004 - gut.bmj.com
Background: Cyclooxygenase 2 (COX-2) and matrix metalloproteinases (MMPs) have been
implicated in tissue injury and fibrogenesis in animal models but little is known regarding …

[HTML][HTML] Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways

…, M Fernández-Velasco, P Martín-Sanz… - Cell Death & …, 2010 - nature.com
P<0.05, ** P<0.01 versus the corresponding condition in the … P<0.05, ** P<0.01 versus the
corresponding condition in the … P<0.05; ** P<0.01 versus the corresponding condition in the …

Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and-9 in fetal rat hepatocytes

…, M Casado, MJM Dı́az-Guerra, L Boscá, P Martı́n-Sanz - Hepatology, 2001 - Elsevier
… Callejas NA, Bosca L, Williams CS, DuBois RN, Martin-Sanz P. Regulation of cyclooxygenase
2 expression in hepatocytes by CCAAT/enhancerbinding proteins. Gastroenterology 2000;…

Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages

…, A Castrillo, P Martín-Sanz… - The Journal of …, 1999 - journals.aai.org
Triggering of the macrophage cell line RAW 264.7 with LPS promotes a transient activation
of phosphatidylinositol 3-kinase (PI3-kinase). Incubation of activated macrophages with …

Prostaglandin E 2 promotes migration and adhesion in hepatocellular carcinoma cells

…, A Fernández-Martínez, L Boscá, P Martín-Sanz - …, 2005 - academic.oup.com
… The results were considered significant at P < 0.05. Data were analyzed by SPSS for
Windows … P < 0.05 versus cells without DFU treatment. See online supplementary material. …

Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C

…, M Casado, L Boscá, ÁM Valverde, P Martín-Sanz - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: We aimed to elucidate whether hepatic insulin resistance may
contribute to hepatocyte apoptosis and fibrogenesis in nonalcoholic fatty liver disease (NAFLD) …