User profiles for P. McDevitt

Jason P. McDevitt

- Verified email at wm.edu - Cited by 1283

Patrick F. McDevitt

- Verified email at buffalo.edu - Cited by 435

[PDF][PDF] A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC

…, J Kasparec, X Tian, KC McNulty, M Rouse, P McDevitt… - Cancer cell, 2015 - cell.com
Epigenetic dysregulation has emerged as an important mechanism in cancer. Alterations in
epigenetic machinery have become a major focus for targeted therapies. The current report …

[HTML][HTML] Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality

…, PH Liang, CA Janson, PJ McDevitt… - Journal of Biological …, 2000 - ASBMB
Caspases have been strongly implicated to play an essential role in apoptosis. A critical
question regarding the role(s) of these proteases is whether selective inhibition of an effector …

[BOOK][B] May the best man win: Sport, masculinity, and nationalism in Great Britain and the empire, 1880-1935

P McDevitt - 2004 - books.google.com
… John and Joyce McDevitt, my siblings and siblings-in-law, Michael and Janet McDevitt, Beth
… Finally, my love, devotion, and admiration for my wife, Sheila Zamor McDevitt, are unending …

[HTML][HTML] Structural basis for Chk1 inhibition by UCN-01

B Zhao, MJ Bower, PJ McDevitt, H Zhao… - Journal of Biological …, 2002 - ASBMB
Chk1 is a serine-threonine kinase that plays an important role in the DNA damage response,
including G 2 /M cell cycle control. UCN-01 (7-hydroxystaurosporine), currently in clinical …

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

…, M Huddleston, S Liu, AF Zmoos, P McDevitt… - Epigenetics, 2012 - Taylor & Francis
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here
we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel …

Crystal structure of Staphylococcus aureus tyrosyl‐tRNA synthetase in complex with a class of potent and specific inhibitors

…, SM Green, P McDevitt, K Johanson, P Carter… - Protein …, 2001 - Wiley Online Library
SB‐219383 and its analogues are a class of potent and specific inhibitors of bacterial tyrosyl‐tRNA
synthetases. Crystal structures of these inhibitors have been solved in complex with …

Muscular Catholicism: Nationalism, masculinity and Gaelic team sports, 1884–1916

PF McDevitt - Gender & History, 1997 - Wiley Online Library
This article examines the highly gendered nature of the games of hurling and Gaelic football
as propagated by the Gaelic Athletic Association from 1884 to 1916 and the relationship of …

Discovery of a novel 2, 6-disubstituted glucosamine series of potent and selective hexokinase 2 inhibitors

…, T Cecconie, S Martens, PJ McDevitt… - ACS medicinal …, 2016 - ACS Publications
A novel series of potent and selective hexokinase 2 (HK2) inhibitors, 2,6-disubstituted
glucosamines, has been identified based on HTS hits, exemplified by compound 1. Inhibitor-…

An overview of the history and current status of clergy health

RJ Proeschold-Bell, PJ McDevitt - Journal of Prevention & …, 2012 - Taylor & Francis
At one time, clergy were thought to be some of the healthiest people in the world. Demographers
Haitung King and John C. Bailar, III (1969) searched through four centuries worth of …

Discovery of novel cyanamide-based inhibitors of cathepsin C

…, B Zhao, J Villa, J Schneck, P McDevitt… - ACS medicinal …, 2011 - ACS Publications
The discovery of potent and selective cyanamide-based inhibitors of the cysteine protease
cathepsin C is detailed. Optimization of the template with regard to plasma stability led to the …