User profiles for Pamela K. Hanson

Pamela Hanson

Professor of Biology, Furman University
Verified email at furman.edu
Cited by 524

[HTML][HTML] Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine

PK Hanson, L Malone, JL Birchmore… - Journal of biological …, 2003 - ASBMB
The alkylphosphocholine class of drugs, including edelfosine and miltefosine, has recently
shown promise in the treatment of protozoal and fungal diseases, most notably, leishmaniasis…

Linking Chemistry and Biology through Course-Based Undergraduate Research on Anticancer Ruthenium Complexes

PK Hanson, LK Stultz - Journal of Chemical Education, 2021 - ACS Publications
Course-based undergraduate research experiences (CUREs) allow students to apply the
scientific method to novel questions, which can serve as a gateway for mentored research. …

Saccharomyces cerevisiae: A Unicellular Model Genetic Organism of Enduring Importance

PK Hanson - Current protocols essential laboratory techniques, 2018 - Wiley Online Library
Though perhaps best known for its roles in baking and brewing, the budding yeast Saccharomyces
cerevisiae is found in a wide range of habitats and has been adapted for use in the …

The anticancer ruthenium complex KP1019 induces DNA damage, leading to cell cycle delay and cell death in Saccharomyces cerevisiae

…, JT McCarty, ME Miller, LK Stultz, PK Hanson - Molecular …, 2013 - ASPET
The anticancer ruthenium complex trans-[tetrachlorobis(1H-indazole)ruthenate(III)], otherwise
known as KP1019, has previously been shown to inhibit proliferation of ovarian tumor cells…

NBD‐labeled phosphatidylcholine and phosphatidylethanolamine are internalized by transbilayer transport across the yeast plasma membrane

AM Grant, PK Hanson, L Malone, J Wylie Nichols - Traffic, 2001 - Wiley Online Library
The internalization and distribution of fluorescent analogs of phosphatidylcholine (M‐C6‐NBD‐PC)
and phosphatidylethanolamine (M‐C6‐NBD‐PE) were studied in Saccharomyces …

A yeast model system for functional analysis of the Niemann–Pick type C protein 1 homolog, Ncr1p

AC Berger, PK Hanson, J Wylie Nichols, AH Corbett - Traffic, 2005 - Wiley Online Library
Niemann–Pick disease type C (NP‐C) is a progressive, ultimately fatal, autosomal recessive
neurodegenerative disorder. The major biochemical hallmark of the disease is the …

[HTML][HTML] Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1

SS Johnson, PK Hanson, R Manoharlal… - Journal of biological …, 2010 - ASBMB
Ceramide is produced by the condensation of a long chain base with a very long chain fatty
acid. In Saccharomyces cerevisiae, one of the two major long chain bases is called …

NBD-labeled phosphatidylcholine enters the yeast vacuole via the pre-vacuolar compartment

PK Hanson, AM Grant, JW Nichols - Journal of cell science, 2002 - journals.biologists.com
At low temperature, the short-chain fluorescent-labeled phospholipids,1-myristoyl-2-[6-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl]-phosphatidylcholine
(MC 6 -NBD-PC) and its …

[HTML][HTML] Energy-dependent flip of fluorescence-labeled phospholipids is regulated by nutrient starvation and transcription factors, PDR1 and PDR3

PK Hanson, JW Nichols - Journal of Biological Chemistry, 2001 - ASBMB
The yeast Saccharomyces cerevisiae readily accumulates short-chain, fluorescent 7-nitrobenz-2-oxa-1,3-diazol-4-yl
(NBD)-labeled phosphatidylcholine and phosphatidylethanolamine …

Proteomic analysis of the S. cerevisiae response to the anticancer ruthenium complex KP1019

…, J O'Leary, E Blatt, M Miller, J Mobley, PK Hanson - Metallomics, 2020 - academic.oup.com
Like platinum-based chemotherapeutics, the anticancer ruthenium complex indazolium
trans-[tetrachlorobis(1H-indazole)ruthenate(iii)], or KP1019, damages DNA, induces apoptosis, …