Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated.
Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis …

The nuclear receptors REV-ERBα (encoded by NR1D1) and REV-ERBβ (NR1D2) have
remained orphans owing to the lack of identified physiological ligands. Here we show that heme …

Cholesterol is required for normal cellular and physiological function, yet dysregulation of
cholesterol metabolism is associated with diseases such as atherosclerosis. Cholesterol …

The nuclear hormone receptor, REV-ERB, plays an essential role in adipogenesis. Rev-erbα
expression is induced in 3T3-L1 cells during adipogenesis, and overexpression of this …

Objective: Understanding the regulation of adipocyte differentiation by cellular and extracellular
factors is crucial for better management of chronic conditions such as obesity, insulin …

The p53 tumor suppressor protein is phosphorylated and activated by several DNA damage-inducible
kinases, such as ATM, and is a key effector of the DNA damage response by …

OBJECTIVE—Human adenovirus type 36 (Ad-36) increases adiposity but improves insulin
sensitivity in experimentally infected animals. We determined the ability of Ad-36 to increase …

OBJECTIVE—Experimental infection of rats with human adenovirus type 36 (Ad-36)
promotes adipogenesis and improves insulin sensitivity in a manner reminiscent of the …

The nuclear hormone receptors, REV-ERBα [NR1D1] and REV-ERBβ [NR1D1], were recently
demonstrated to be receptors for the porphyrin, heme. Heme regulates the ability of these …

Several metabolic abnormalities are associated with relative excess or deficiency of adipose
tissue. Identifying the regulators of adipogenic differentiation is critical for its successful …