User profiles for Patric J. Jansson

Jan Patric Jansson

Senior Lecturer and Senior Research Fellow
Verified email at sydney.edu.au
Cited by 19384

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors

…, Z Kovacevic, AR Siafakas, PJ Jansson… - Journal of medicinal …, 2009 - ACS Publications
The chemical and biological effects of thiosemicarbazones have received considerable
interest from medicinal chemists for many years. This is attributed to, first, their wide …

Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes

DB Lovejoy, PJ Jansson, UT Brunk, J Wong, P Ponka… - Cancer research, 2011 - AACR
The metal-chelating compound Dp44mT is a di-2-pyridylketone thiosemicarbazone (DpT)
which displays potent and selective antitumor activity. This compound is receiving translational …

Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: identification of pronounced redox activity and characterization of their antitumor …

PJ Jansson, PC Sharpe, PV Bernhardt… - Journal of medicinal …, 2010 - ACS Publications
The novel chelators 2-acetylpyridine-4,4-dimethyl-3-thiosemicarbazone (HAp44mT) and di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone
(HDp44mT) have been examined to …

Molecular pharmacology of ABCG2 and its role in chemoresistance

AE Stacy, PJ Jansson, DR Richardson - Molecular pharmacology, 2013 - ASPET
The ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) is an important member
of the ABC transporter superfamily, which has been suggested to be involved in multidrug …

[HTML][HTML] Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

J Paluncic, Z Kovacevic, PJ Jansson… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Melanoma has markedly increased worldwide during the past several decades in the
Caucasian population and is responsible for 80% of skin cancer deaths. Considering that …

[HTML][HTML] P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration

…, S Sahni, DM Sharp, A Arvind, PJ Jansson… - Journal of Biological …, 2013 - ASBMB
Localization of the drug transporter P-glycoprotein (Pgp) to the plasma membrane is thought
to be the only contributor of Pgp-mediated multidrug resistance (MDR). However, very little …

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung …

…, MT Basha, PC Sharpe, PJ Jansson… - Journal of medicinal …, 2012 - ACS Publications
We developed a series of second-generation di-2-pyridyl ketone thiosemicarbazone (DpT)
and 2-benzoylpyridine thiosemicarbazone (BpT) ligands to improve the efficacy and safety …

The old and new biochemistry of polyamines

DH Bae, DJR Lane, PJ Jansson… - Biochimica et Biophysica …, 2018 - Elsevier
Polyamines are ubiquitous positively charged amines found in all organisms. These molecules
play a crucial role in many biological functions including cell growth, gene regulation and …

Zinc (II)–thiosemicarbazone complexes are localized to the lysosomal compartment where they transmetallate with copper ions to induce cytotoxicity

…, DS Kalinowski, PJ Jansson… - Journal of medicinal …, 2016 - ACS Publications
As the di-2-pyridylketone thiosemicarbazone (DpT) and 2-acetylpyridine thiosemicarbazone
(ApT) series show potent antitumor activity in vitro and in vivo, we synthesized their …

Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy

…, KC Park, DS Kalinowski, PJ Jansson… - … et Biophysica Acta (BBA …, 2014 - Elsevier
N-myc down-regulated gene 1 (NDRG1) is a known metastasis suppressor in multiple cancers,
being also involved in embryogenesis and development, cell growth and differentiation, …