Background Engineered iron nanoparticles are being explored for the development of
biomedical applications and many other industry purposes. However, to date little is known …

The antioxidant‐activated transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2)
regulates the induction of cytoprotective genes against chemical toxicity and oxidative …

Genetic and biochemical analyses have uncovered an essential role for nuclear factor
erythroid 2-related factor 2 (Nrf2) in regulating phase II xenobiotic metabolism and antioxidant …

Non-small cell lung cancer (NSCLC) is the major form of lung cancer, with adenocarcinoma
(LUAD) and squamous cell carcinoma (LUSC) being its major subtypes. Smoking alone …

Human platelet-type 12-lipoxygenase (12-LOX) has recently been shown to play an
important role in regulation of human platelet function by reacting with arachidonic acid (AA). …

Following initial platelet activation, arachidonic acid is metabolised by cyclooxygenase-1
and 12-lipoxygenase (12-LOX). While the role of 12-LOX in the platelet is not well defined, …

Objective— The rate-limiting step in the biosynthesis of thromboxane A 2 (TxA 2 ) and 12-hydroxyeicosatetraenoic
acid (12-HETE) by platelets is activation of cytosolic phospholipase A …

Platelet activation is important in the regulation of hemostasis and thrombosis. Uncontrolled
activation of platelets may lead to arterial thrombosis, which is a major cause of myocardial …

The Ca-ATPase of sarcoplasmic reticulum removes cytosolic calcium to promote muscle
relaxation. In the heart, the Ca-ATPase is regulated by phospholamban, which inhibits the Ca-…

Environmental pollutants and toxicants expose cells to oxidative and electrophilic challenges.
Oxidative and xenobiotic stresses caused by environmental toxicants are known to cause …