Human beings have been reflect ing on how fishes propel them selves through water for a
re markably long time. Some of the earliest thoughts on how fishes swim were re corded in …

The challenges associated with synthesizing porous materials 1 mean that new classes of
zeolites (zeotypes)—such as aluminosilicate zeolites 2 , 3 and zeolite analogues 4 —together …

The transactivation properties of the two estrogen receptors, ERα and ERβ, were examined
with different ligands in the context of an estrogen response element and an AP1 element. …

Elections lie at the heart of the relationship between parties and democracy. Just as it is
impossible to conceive of a definition of representative democracy which does not place …

… In the course of working on the book, Paul Webb benefited greatly from a highly productive,
if all too brief, Visiting Fellowship at the Australian National University during the final …

Four functional categories are denned to embrace the range of locomotor diversity of aquatic
vertebrates; (1) body/caudal fin (BCF) periodic propulsion where locomotor movements …

Estrogen receptor (ER) binds to estrogen response elements in target genes and recruits a
coactivator complex of CBP-pl60 that mediates stimulation of transcription. ER also activates …

We find that tamoxifen is a potent activator of estrogen receptor (ER)- mediated induction of
promoters regulated by AP-1 sites including the human collagenase gene promoter and …

We describe the biological properties of NVP-AUY922, a novel resorcinylic isoxazole amide
heat shock protein 90 (HSP90) inhibitor. NVP-AUY922 potently inhibits HSP90 (K d = 1.7 …

Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as
potential chemotherapeutic agents for cancer. Here, we describe the structure-based design, …