Differences in signal transduction of two 5-HT4Receptor splice variants: compound specificity and dual coupling with Gαs-and Gαi/o-proteins
A Pindon, G Van Hecke, P Van Gompel… - Molecular …, 2002 - ASPET
This study documents differences in ligand binding and signal transduction properties
between the human (h) 5-hydroxytryptamine (5-HT) 4a and h5-HT 4b receptor splice variants …
between the human (h) 5-hydroxytryptamine (5-HT) 4a and h5-HT 4b receptor splice variants …
[HTML][HTML] Binding of GDNF and Neurturin to Human GDNF Family Receptor α 1 and 2: INFLUENCE OF cRET AND COOPERATIVE INTERACTIONS
…, ASJ Lesage, I Van der Linden, P Van Gompel… - Journal of Biological …, 2000 - ASBMB
The members of the glial cell line-derived neurotrophic factor (GDNF) family signal via
binding to the glycosyl phosphatidylinositol-anchored membrane proteins, the GDNF family …
binding to the glycosyl phosphatidylinositol-anchored membrane proteins, the GDNF family …
Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in …
PJ Pauwels, P Van Gompel, JE Leysen - Biochemical pharmacology, 1993 - Elsevier
The activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists, and
various other neurotransmitter receptor antagonists at human 5-HT 1A receptors that are …
various other neurotransmitter receptor antagonists at human 5-HT 1A receptors that are …
[HTML][HTML] Mammalian GFRα-4, a divergent member of the GFRα family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the …
…, I Van der Linden, R Scott, P Van Gompel… - Journal of Biological …, 2000 - ASBMB
Four members of the glial cell line-derived neurotrophic factor family have been identified (GDNF,
neurturin, persephin, and enovin/artemin). They bind to a specific membrane-…
neurturin, persephin, and enovin/artemin). They bind to a specific membrane-…
Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5‐HT1B and 5‐HT1D receptors expressed in various mammalian cell lines
AS Lesage, R Wouters, P Van Gompel… - British journal of …, 1998 - Wiley Online Library
Alniditan, a novel migraine abortive agent, is a potent 5‐HT 1B /5‐HT 1D receptor agonist of
nM affinity. We compared the agonistic properties of alniditan, sumatriptan and …
nM affinity. We compared the agonistic properties of alniditan, sumatriptan and …
Internalization of Human 5-HT4a and 5-HT4b Receptors is Splice Variant Dependent
A Pindon, GV Hecke, K Josson, PV Gompel, A Lesage… - Bioscience …, 2004 - Springer
The family of 5-HT 4 receptors comprises 16 putative splice variants. We have previously
shown that there are differences in signal transduction of the h5-HT 4a and h5-HT 4b receptors. …
shown that there are differences in signal transduction of the h5-HT 4a and h5-HT 4b receptors. …
Rapid desensitization and resensitization of 5-HT2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle …
PJ Pauwels, P Van Gompel, JE Leysen - Life sciences, 1990 - Elsevier
Agonist regulation of 5-hydroxytryptamine 2 (5-HT 2 ) receptors was studied in calf aortic
smooth muscle cultures incubated in a quiescent, defined synthetic medium that does not …
smooth muscle cultures incubated in a quiescent, defined synthetic medium that does not …
Supersensitivity of human metabotropic glutamate 1a receptor signaling in L929sA cells
H Lavreysen, E Le Poul, P Van Gompel, L Dillen… - Molecular …, 2002 - ASPET
The effect of antagonist pretreatment on the signaling properties of the human metabotropic
glutamate 1a (hmGlu1a) receptor was examined in stably transfected L929sA cells. Pre-…
glutamate 1a (hmGlu1a) receptor was examined in stably transfected L929sA cells. Pre-…
Distinction between adrenergic and serotonergic receptor subtypes: specificity of drugs and absence of cooperative interactions between adrenergic and serotonergic …
JE Leysen, P Van Gompel… - Journal of Cardiovascular …, 1988 - journals.lww.com
: In light of observed amplificatory interactions between serotonergic and adrenergic stimuli
in functional studies on vascular tissue and platelets, we investigated the distinction and …
in functional studies on vascular tissue and platelets, we investigated the distinction and …
In vivo formation of epinine in adrenal medulla: A possible step for adrenaline biosynthesis
P Laduron, P Van Gompel, J Leysen - Naunyn-Schmiedeberg's Archives …, 1974 - Springer
Endogenous epinine was isolated from pig and bovine adrenal medulla and identified by
means of thin layer chromatography and gas chromatography-mass fragmentography. By …
means of thin layer chromatography and gas chromatography-mass fragmentography. By …