Prolactin-releasing peptide (PrRP) and neuropeptide FF (NPFF) are RF-amide peptides
expressed in brain areas involved in pain modulation. NPFF displays multiple effects on acute, …

The histaminergic system in the brain is a phylogenetically old group of neurons that project
to most of the central nervous system. It holds a key position in the regulation of basic body …

Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

… Histaminergic neurons are exclusively found in the tuberomammillary nucleus of the
ventrocaudal hypothalamus (Panula et al., 1984; Steinbusch and Mulder, 1984; Watanabe et al., …

Background—Histamine, a product of mast cells, is an effective vasoconstrictor of atherosclerotic
coronary arteries. Because it has been suggested that coronary spasm plays a role in …

The zebrafish (Danio rerio) has emerged as a powerful model to study vertebrate development
and disease. Its short generation time makes it amenable to genetic manipulation and …

Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important
role in the maintenance of wakefulness, and dysfunction in the histaminergic system has …

We identified the cDNAs of three functional rat H 3 receptor isoforms (H 3A , H 3B , and H 3C
) and one nonfunctional truncated H 3 receptor (H 3T ). The H 3A , H 3B , and H 3C receptor …

The modulatory aminergic neurotransmitters are involved in practically all important
physiological systems in the brain, and many of them are also involved in human central nervous …

The orexin/hypocretin (ORX) system is involved in physiological processes such as feeding,
energy metabolism, and the control of sleep and wakefulness. The ORX system may drive …